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Can I take Aspirin low dose and Magnesium together?

Drug interaction guide

Taking magnesium supplements or antacids containing magnesium at the same time as low-dose aspirin can make the aspirin less effective. This is because magnesium can change how much aspirin your body absorbs and how quickly it leaves your system.

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Why this happens

Magnesium can increase the pH (reduce the acidity) of the stomach and urine. A less acidic stomach can slow down the absorption of aspirin, while less acidic urine causes the kidneys to flush aspirin out of the body more quickly.

To ensure your low-dose aspirin works correctly, try to space the doses apart. Take your aspirin at least 2 hours before or 2 hours after taking any magnesium supplements or magnesium-based antacids.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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