Skip to main content

Can I take Aspixaban and Vitamin k together?

Drug interaction guide

There is no known interaction between apixaban (Eliquis) and Vitamin K. Unlike older blood thinners like warfarin, apixaban works on a different part of the clotting process that does not involve Vitamin K.

Video picks for Drug interactions

Continue reading below

Why this happens

Apixaban is a direct factor Xa inhibitor. It blocks a specific protein in the blood to prevent clots. Warfarin, a different type of blood thinner, works by blocking Vitamin K; therefore, people on warfarin must watch their Vitamin K intake. Because apixaban does not target Vitamin K, eating foods high in Vitamin K (like spinach or kale) or taking Vitamin K supplements will not change how well the medicine works.

You do not need to change your diet or avoid Vitamin K while taking apixaban. You can safely eat green leafy vegetables and take multivitamins containing Vitamin K. However, always inform your doctor or pharmacist before starting any new high-dose supplements.

Continue reading below

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Continue reading below

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
flu eligibility checker

Ask, share, connect.

Browse discussions, ask questions, and share experiences across hundreds of health topics.

symptom checker

Feeling unwell?

Assess your symptoms online for free

Sign up to the Patient newsletter

Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.

Please enter a valid email address

By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.