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Can I take Cordyceps and Maitake together?

Drug interaction guide

Taking cordyceps and maitake together may increase the risk of bruising or bleeding, and could cause your blood sugar levels to drop too low (hypoglycaemia).

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Why this happens

Both mushrooms have 'blood-thinning' properties that prevent platelets from sticking together, and both can lower blood sugar. Taking them together may create an additive effect, strengthening these actions.

Use caution when combining these supplements. If you are scheduled for surgery, stop taking them at least two weeks beforehand. If you have diabetes or take blood-thinning medication (like warfarin), consult your doctor first, as your dosages may need adjusting. Monitor for signs of low blood sugar, such as dizziness or shaking.

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Auto-immune conditions (e.g., multiple sclerosis, lupus, rheumatoid arthritis)

These fungi can stimulate the immune system, which may worsen symptoms of autoimmune conditions or interfere with immunosuppressant medications.

Bleeding disorders or upcoming surgery

Both supplements have blood-thinning effects and can increase the risk of bleeding during and after surgery. Stop taking them at least 2 weeks before any scheduled procedure.

Diabetes

Maitake can significantly lower blood sugar levels. If you are taking insulin or oral diabetes medications, you must monitor your blood sugar closely to avoid dangerous hypoglycaemia.

Alcohol

It is best to avoid or strictly limit alcohol when taking these supplements. Both Cordyceps and Maitake may have blood-sugar lowering effects; alcohol can also cause blood sugar to drop, potentially increasing the risk of hypoglycaemia (low blood sugar). Additionally, alcohol can strain the liver, and the long-term effects of combining these supplements with alcohol are not well-studied.

Caffeine (Coffee, Tea, Energy Drinks)

Cordyceps may have mild stimulant properties. Consuming caffeine alongside this supplement may increase feelings of jitteriness, rapid heartbeat, or difficulty sleeping.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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