Can I take Furosemide and Naproxen together?
Drug interaction guide
Originally published 12 May 2026
Meets Patient’s editorial guidelines
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Taking naproxen can make furosemide less effective at removing excess fluid from your body. This combination can also increase the strain on your kidneys and may lead to a rise in blood pressure.
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Why this happens
Furosemide works by helping the kidneys produce more urine, which requires certain natural chemicals called prostaglandins. Naproxen (an NSAID) blocks these chemicals. This stops the furosemide from working properly and reduces blood flow to the kidneys.
What you should do
Back to contentsSpeak to your doctor before taking these together. If you must take both, your doctor may want to monitor your kidney function and blood pressure regularly. Watch for signs that your furosemide isn't working as well, such as swollen ankles or shortness of breath.
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Important precautions
Back to contentsAsthma
Do not take this medicine if you have asthma, as it can cause a life-threatening allergic reaction or severe worsening of your breathing.
Kidney impairment
Taking these two medicines together significantly increases the risk of sudden kidney failure. Your doctor must monitor your kidney function closely.
Stomach ulcers or bleeding
Naproxen can cause serious stomach bleeding and ulcers. Seek immediate medical help if you vomit blood or pass black, tarry stools.
Food and drink warnings
Back to contentsAlcohol
Drinking alcohol while taking furosemide can increase the risk of dizziness, lightheadedness, or fainting, as both can lower your blood pressure. It is best to limit alcohol intake, especially when you first start taking this medicine or if your dose is increased.
Food (General)
Naproxen should ideally be taken with or after food, or with a glass of milk. This helps to protect your stomach lining and reduces the risk of indigestion or stomach upset.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
12 May 2026 | Originally published
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