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Can I take Lercanidipine and Promethazine together?

Drug interaction guide

Taking these two medicines together can cause your blood pressure to drop lower than intended. This might make you feel dizzy, lightheaded, or faint, especially when standing up quickly. Additionally, both drugs can cause drowsiness, which may be more intense when they are used at the same time.

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Why this happens

Lercanidipine works by relaxing your blood vessels to lower blood pressure. Promethazine, while primarily an antihistamine, can also cause blood vessels to widen slightly and has a sedating effect on the brain. When combined, these effects add together, increasing the risk of low blood pressure and sleepiness.

What you should do

You should use caution when taking these medicines together. Monitor your blood pressure regularly and be careful when getting out of bed or standing up. If you feel very dizzy or sleepy, avoid driving or operating machinery. If you experience fainting or severe dizziness, contact your doctor to see if your doses need adjusting.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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