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Can I take Amoxicillin and Cannabis together?

Drug interaction guide

There is no known direct interaction between amoxicillin and cannabis. However, using cannabis while you have an infection may make you feel more dizzy or drowsy, and smoking it can irritate your lungs, potentially slowing down your recovery from respiratory infections.

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Why this happens

Amoxicillin is primarily cleared by the kidneys, while the active compounds in cannabis (THC and CBD) are processed by the liver. Because they use different pathways, they do not interfere with how the body breaks each medicine down. There are no shared effects on the body's systems that would cause a dangerous reaction.

What you should do

It is generally safe to take amoxicillin if you use cannabis, but it is best to avoid smoking if your infection affects your chest or throat. Be aware that the combined effects might make you feel more tired than usual. Always finish the full course of antibiotics as prescribed by your doctor.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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