Can I take Naproxen bp and Oxypro together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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Taking these two medicines together significantly increases your risk of serious stomach problems, such as stomach ulcers, bleeding, or irritation of the stomach lining. It can also increase the risk of kidney problems.
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Why this happens
Both naproxen and oxypro (which contains naproxen) are types of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). Taking two different NSAIDs at the same time does not provide extra pain relief but does double the risk of side effects, particularly damage to the stomach lining and strain on the kidneys.
What you should do
Do not take these two medicines together. Oxypro already contains naproxen as its active ingredient. Taking both would result in an accidental overdose of the same drug. If your pain is not well-controlled, speak to your doctor or pharmacist about adding a different type of painkiller, such as paracetamol.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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