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Can I take Omeprazole and Pyridostigmine together?

Drug interaction guide

Omeprazole may reduce the effectiveness of pyridostigmine, potentially causing your muscle weakness symptoms to return or worsen.

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Why this happens

Pyridostigmine works best in an acidic stomach environment. Omeprazole reduces stomach acid, which can prevent pyridostigmine from being absorbed properly into your bloodstream.

What you should do

Speak to your doctor before taking these together. They may suggest timing the doses further apart or monitoring your symptoms closely. If you notice increased muscle weakness or difficulty swallowing, contact your healthcare provider immediately.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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