Can I take Omeprazole and Pyridostigmine together?
Drug interaction guide
Originally published 25 Jan 2026
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Omeprazole may reduce the effectiveness of pyridostigmine, potentially causing your muscle weakness symptoms to return or worsen.
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Why this happens
Pyridostigmine works best in an acidic stomach environment. Omeprazole reduces stomach acid, which can prevent pyridostigmine from being absorbed properly into your bloodstream.
What you should do
Back to contentsSpeak to your doctor before taking these together. They may suggest timing the doses further apart or monitoring your symptoms closely. If you notice increased muscle weakness or difficulty swallowing, contact your healthcare provider immediately.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Taking lisinopril and potassium supplements together can cause the levels of potassium in your blood to become dangerously high (a condition called hyperkalaemia). While your body needs potassium for your heart and muscles to work, too much of it can lead to serious heart rhythm problems or even cause the heart to stop. Symptoms of high potassium can include muscle weakness, tingling sensations, or palpitations, but often there are no symptoms until the level is very high.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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