Can I take Oxycodone and Paracetamol together?

Why this happens

These drugs work in different ways to block pain (oxycodone works on the brain and central nervous system, while paracetamol works more on the peripheral nerves). Because they use different pathways, they have an 'additive' effect, meaning they boost each other's pain-killing power. They do not significantly change how the other is absorbed or broken down by the body.

What you should do

It is usually safe to take these together if they have been prescribed that way by a doctor. However, you must check the packaging of your oxycodone carefully to see if it already contains paracetamol. Do not exceed the maximum daily dose of paracetamol (usually 4000mg or eight 500mg tablets in 24 hours). It is best to avoid or strictly limit alcohol when taking this combination, as both paracetamol and alcohol can strain the liver, and alcohol increases the sedative effects of oxycodone.

Important precautions

Opioid dependence/Addiction

Oxycodone is highly addictive. Long-term use can lead to physical dependence and withdrawal symptoms if stopped suddenly.

Respiratory depression

Oxycodone can dangerously slow or stop your breathing, especially when first starting or if the dose is increased. This risk is much higher if taken with alcohol or other sedatives.

Liver damage (Overdose)

Taking more than the recommended dose of paracetamol can cause fatal liver failure. You must check all other medicines (like cold and flu remedies) to ensure they do not also contain paracetamol.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol when taking these medicines. Combining alcohol with paracetamol increases the risk of liver damage. Combining alcohol with oxycodone can cause dangerous levels of drowsiness, breathing difficulties, and a fatal overdose.

Grapefruit juice

Avoid drinking grapefruit juice or eating grapefruit while taking oxycodone. Grapefruit can increase the amount of oxycodone in your blood, which makes side effects like extreme sleepiness and slowed breathing more likely.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.