Can I take Prozac and Venlafaxine together?

Why this happens

Both medications increase serotonin levels in the brain (pharmacodynamic interaction). Furthermore, Prozac is a strong inhibitor of the liver enzyme (CYP2D6) responsible for clearing venlafaxine from your system, which can lead to a toxic buildup of venlafaxine (pharmacokinetic interaction).

What you should do

You should not take these two medications together unless specifically instructed and closely monitored by a specialist. If you are currently taking both and experience agitation, hallucinations, a very fast heartbeat, or muscle twitching, seek emergency medical help immediately. Always consult your doctor before making any changes to your antidepressant medication.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.