Can I take Ramapril and Spironolactone together?

Why this happens

Both ramipril (an ACE inhibitor) and spironolactone (a potassium-sparing diuretic) work in ways that reduce the amount of potassium your body gets rid of through your urine. When used together, their effects add up, making it much easier for potassium to build up to unsafe levels.

What you should do

You must have regular blood tests to monitor your potassium levels and kidney function, especially when starting these medicines or changing the dose. Avoid using salt substitutes (like Lo-Salt) or potassium supplements unless your doctor specifically tells you to, as these contain high amounts of potassium. Contact your doctor immediately if you feel unusually tired, have muscle weakness, or feel a fluttering in your chest.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.