Can I take Ramipril and Sertraline together?

Why this happens

Both ramipril (an ACE inhibitor) and sertraline (an SSRI antidepressant) are known to independently cause the body to retain water and lose sodium. When used together, this effect is added together. Furthermore, sertraline affects how platelets (cells that help blood clot) work, while ramipril can sometimes affect blood vessels, slightly increasing the chance of bruising or bleeding.

What you should do

It is generally safe to take these together, but you should be aware of the symptoms of low sodium. Contact your doctor if you experience unusual tiredness, confusion, muscle weakness, or persistent headaches. Your doctor may want to perform a simple blood test to check your sodium levels shortly after you start taking both medicines. You should also report any unusual bruising or dark, tarry stools to your GP.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.