Can I take Sertraline and Citalopram together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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Taking sertraline and citalopram together significantly increases the risk of a rare but serious condition called serotonin syndrome. This happens when there is too much of the chemical serotonin in your brain. Symptoms can include feeling very agitated, confused, or shaky, as well as sweating, a fast heartbeat, muscle twitching, or diarrhoea. There is also an increased risk of a specific heart rhythm problem called QT prolongation, which can cause fainting or palpitations.
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Why this happens
Both sertraline and citalopram belong to the same class of medicines called Selective Serotonin Reuptake Inhibitors (SSRIs). Because they work in the exact same way to increase serotonin levels, taking them together creates an 'additive effect' where the levels become dangerously high. Additionally, both drugs can affect the electrical activity of the heart in a similar way.
What you should do
You should not take these two medicines together unless specifically instructed and closely monitored by a specialist. If you are currently taking both, do not stop taking them suddenly, but contact your doctor immediately to discuss a safe plan. Seek urgent medical help if you experience a very fast or irregular heartbeat, severe dizziness, or significant confusion.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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