Can I take Atorvastatin and Royal sun together?
Drug interaction guide
Originally published 24 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
Taking Royal Sun (Agaricus blazei) alongside atorvastatin may increase the risk of liver irritation or damage. Both substances are processed by the liver, and there have been rare reports of this mushroom causing liver inflammation (hepatitis). Combining them could potentially put extra strain on your liver.
In this article:
Video picks for Drug interactions
Why this happens
Both atorvastatin and Royal Sun mushroom can affect liver enzymes. While atorvastatin is a well-known cause of rare liver side effects, Royal Sun contains compounds that have been linked to liver toxicity in some case studies. Taking them together may have an additive effect on liver stress.
What you should do
Back to contentsUse caution when combining these two. Before starting Royal Sun, you should speak with your doctor or pharmacist. If you decide to take both, watch out for signs of liver problems, such as yellowing of the eyes or skin (jaundice), dark urine, or pain in the upper right side of your stomach. Your doctor may want to perform routine blood tests to check your liver function.
Continue reading below
Important precautions
Back to contentsPregnancy
You must not take atorvastatin if you are pregnant or planning to become pregnant, as it can cause serious harm to an unborn baby. Use effective contraception while taking this medicine.
Muscle disorders - atorvastatin
Seek immediate medical advice if you experience unexplained muscle pain, tenderness, or weakness. In rare cases, this can lead to a serious condition called rhabdomyolysis which causes kidney damage.
Food and drink warnings
Back to contentsGrapefruit juice
Grapefruit juice contains compounds that can increase the level of atorvastatin in your blood. This may increase your risk of side effects, such as muscle pain or damage. Avoid drinking large quantities (more than 1.2 litres per day), though it is safest to avoid it altogether or keep intake to very small amounts.
Alcohol
While alcohol does not directly interact with atorvastatin, drinking large amounts of alcohol can increase the risk of liver problems and muscle side effects. It is best to keep your intake within the recommended limits (no more than 14 units per week).
Continue reading below
Using other medicines?
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Lions mane and White button together?
There are no known harmful interactions between Lion's Mane (Hericium erinaceus) and White Button mushrooms (Agaricus bisporus). Both are edible fungi that are commonly consumed as food or supplements.

Treatment and medication
Can I take Lions mane and Reisha together?
Both Lion's Mane and Reishi mushrooms have natural blood-thinning properties. Taking them together might increase the risk of bruising or bleeding, especially if you are already taking blood-thinning medication or have an upcoming surgery. Additionally, both may lower blood sugar levels, which could lead to feeling dizzy or shaky if levels drop too low.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
24 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.