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Can I take Azithromycin and Terbutaline together?

Drug interaction guide

Taking azithromycin and terbutaline together may increase the risk of developing an irregular heart rhythm. While this is rare, it can be serious. Symptoms to watch out for include heart palpitations (a fluttering feeling in the chest), dizziness, fainting, or sudden shortness of breath.

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Why this happens

Both of these medicines have the potential to slightly affect the electrical activity of your heart (specifically, they can prolong the 'QT interval'). When used at the same time, their effects can add together, making an irregular heartbeat more likely.

What you should do

Speak to your doctor before taking these together, especially if you have a history of heart problems or low levels of potassium or magnesium in your blood. If your doctor has prescribed both, follow their instructions closely. Seek immediate medical help if you feel your heart is beating irregularly, or if you feel faint or dizzy.

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Important precautions

Heart rhythm disorders (Long QT syndrome)

Azithromycin can cause serious changes to your heart rhythm. You must inform your doctor if you have a history of heart palpitations, a slow heart rate, or a family history of 'Long QT syndrome'.

Diabetes

Terbutaline can cause your blood sugar levels to rise. If you have diabetes, you may need to monitor your blood glucose more frequently when starting treatment or increasing your dose.

Food and drink warnings

Caffeine (Coffee, tea, energy drinks, cola)

Terbutaline is a stimulant that can increase your heart rate. Consuming caffeine while taking this medicine may increase the risk of side effects like a racing heart, palpitations, or feeling shaky/jittery.

Food (General)

If you have been prescribed azithromycin in capsule form, you must take it at least 1 hour before food or 2 hours after food. Food significantly reduces the absorption of the capsules. Note: This does not apply to azithromycin tablets or liquid suspension, which can be taken with or without food.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 24 Jan 2026 | Originally published
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