Can I take Co-codamol and Ibuprofen together?

Why this happens

Co-codamol contains paracetamol and codeine. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID). Because they belong to different drug classes and target pain through different pathways in the body, they have an 'additive' effect, meaning they work together to manage pain more effectively without interfering with how each drug is absorbed or processed.

What you should do

You can take these two medicines at the same time, or you can stagger them (for example, taking ibuprofen two hours after your co-codamol). Always follow the dosage instructions on the packaging. Do not take any other products containing paracetamol while taking co-codamol, as this could lead to a dangerous overdose. If you have a history of stomach ulcers, asthma, or kidney problems, speak to a pharmacist before taking ibuprofen.

Important precautions

Paracetamol overdose risk

Do not take any other medicines containing paracetamol while taking co-codamol. Taking too much paracetamol can cause serious, permanent liver damage. Check the labels of all cold and flu remedies.

Asthma and stomach ulcers

Do not take ibuprofen if you have ever had a stomach ulcer, perforation, or bleeding. If you have asthma, ibuprofen can cause a life-threatening worsening of your breathing; do not take it if you have previously reacted to aspirin or other NSAIDs.

Opioid addiction and withdrawal

Co-codamol contains codeine, which is addictive. Do not use it for more than 3 days in a row. If you take it for longer, you may experience withdrawal symptoms like restlessness and irritability when you stop.

Food and drink warnings

Alcohol

You must avoid drinking alcohol while taking co-codamol. Combining alcohol with codeine increases the risk of serious side effects, such as extreme sleepiness, breathing difficulties, and loss of consciousness. Both alcohol and paracetamol can also strain the liver.

Caffeine (Coffee, tea, cola, energy drinks)

Limit your intake of caffeine-containing drinks. Some co-codamol preparations already contain caffeine. Excessive caffeine can lead to nervousness, tremors, and a rapid heartbeat.

Food (General)

While not an interaction that changes how the drug works, you should always take ibuprofen with food or a glass of milk. This helps to protect your stomach lining and reduces the risk of indigestion or stomach upset.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.