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Can I take Lions mane and Maitake together?

Drug interaction guide

Both Lion's Mane and Maitake mushrooms may lower blood sugar levels and slow down blood clotting. Taking them together might increase the risk of your blood sugar dropping too low (hypoglycaemia) or increase the chance of bruising and bleeding.

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Why this happens

These supplements have 'additive' effects. This means they work in similar ways: both contain compounds (like beta-glucans) that can improve insulin sensitivity and others that may prevent blood platelets from sticking together. When combined, these effects can become stronger.

What you should do

This combination is usually fine for most healthy people, but you should use caution. If you have diabetes or take blood-thinning medication (like warfarin or aspirin), speak to your doctor before mixing them. Monitor your blood sugar levels closely and watch for signs of easy bruising or nosebleeds. If you have an upcoming surgery, stop taking both at least two ages beforehand.

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Using other medicines?

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 24 Jan 2026 | Originally published
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