Can I take Mounjaro and Paracetamol together?

Why this happens

Mounjaro (tirzepatide) works by slowing down 'gastric emptying'—the speed at which your stomach empties its contents into your intestines. Since paracetamol is absorbed in the small intestine, delaying the time it takes to leave the stomach can delay its effects.

What you should do

You can take these medicines together, but be aware that the paracetamol might take longer than usual to kick in. Do not take extra doses of paracetamol if you don't feel immediate relief, as this could lead to an overdose. If you need rapid pain relief for an acute issue (like a sudden migraine), talk to your pharmacist or doctor.

Important precautions

Pancreatitis

Stop using this medicine and seek immediate medical help if you experience severe, persistent stomach pain that may radiate to your back, as this can be a sign of acute pancreatitis.

Liver health and multi-ingredient medicines

Never take more than the maximum dose (usually 8 tablets in 24 hours) or combine with other products containing paracetamol (such as Lemsip or Night Nurse), as even a small overdose can cause fatal liver damage.

Severe dehydration and kidney injury

This medicine can cause severe vomiting and diarrhoea; you must drink plenty of fluids to avoid dehydration, which can lead to sudden kidney failure.

Food and drink warnings

Alcohol

Alcohol can affect your blood sugar levels and increase the risk of hypoglycaemia (low blood sugar). Additionally, both Mounjaro and alcohol can cause gastrointestinal side effects like nausea and vomiting; combining them may make these symptoms worse.

Large meals / High-fat foods

Mounjaro slows down how quickly your stomach empties. Eating very large or high-fat meals can lead to significant discomfort, bloating, and nausea because the food stays in your stomach longer. It is often recommended to eat smaller portions and stop when you feel full.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.