Can I take Omeprazole and Ibuprofen together?
Drug interaction guide
Originally published 24 Jan 2026
Meets Patient’s editorial guidelines
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Taking these two medicines together is generally safe and is often done intentionally. Omeprazole can actually help protect your stomach from the irritation or ulcers that ibuprofen can sometimes cause. However, there is a very small chance that omeprazole might slightly reduce how quickly or effectively the ibuprofen works for pain relief, though most people do not notice this.
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Why this happens
Ibuprofen can irritate the stomach lining and increase the risk of stomach ulcers. Omeprazole reduces the amount of acid your stomach produces, which provides a protective layer and lowers the risk of these side effects. From a chemical standpoint, omeprazole raises the pH (lowers the acidity) of the stomach, which can theoretically change how quickly ibuprofen dissolves and is absorbed into the bloodstream, but this is rarely a problem in practice.
What you should do
You can take these medicines together. In fact, if you need to take ibuprofen regularly, your doctor may have prescribed omeprazole specifically to protect your stomach. If you find your pain relief is not as effective as usual, speak to a pharmacist or doctor. Always take ibuprofen with food to further protect your stomach.
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Important precautions
Asthma
Do not take this medicine if you have asthma, as it can cause a life-threatening worsening of your breathing or a severe allergic reaction.
Stomach ulcers or bleeding
Avoid this medicine if you have ever had a stomach ulcer or gastrointestinal bleeding. Taking it alongside omeprazole may mask the symptoms of new stomach damage.
Pregnancy (third trimester)
Do not take ibuprofen if you are more than 28 weeks pregnant, as it can cause serious heart and kidney problems in the unborn baby and complications during delivery.
Food and drink warnings
Alcohol
Drinking alcohol while taking ibuprofen can increase the risk of stomach irritation and serious side effects like stomach bleeding or ulcers. It is best to limit or avoid alcohol while taking this medicine.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
24 Jan 2026 | Originally published
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