Can I take Sertraline and Fluoxetine together?
Drug interaction guide
Originally published 24 Jan 2026
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Taking sertraline and fluoxetine together significantly increases the risk of a rare but serious condition called serotonin syndrome. This happens because both medicines work by increasing the level of a chemical called serotonin in your brain. If levels get too high, it can cause symptoms like shivering, diarrhoea, confusion, severe muscle tightness, fever, and even seizures. Additionally, fluoxetine can slow down how your body breaks down sertraline, leading to a build-up of the drug in your system and increasing the risk of side effects.
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Why this happens
Both drugs are Selective Serotonin Reuptake Inhibitors (SSRIs) that have an additive effect on serotonin levels (pharmacodynamic interaction). Furthermore, fluoxetine interferes with the liver enzymes (specifically CYP2D6 and potentially others) responsible for clearing sertraline from your body, making sertraline levels rise higher than intended (pharmacokinetic interaction).
What you should do
You should not take these two medicines together unless specifically instructed and closely monitored by a specialist. If you are currently taking both, do not stop taking them abruptly, but contact your doctor immediately to discuss a safe plan. Seek urgent medical help if you experience agitation, hallucinations, a very fast heartbeat, or muscle twitching.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
24 Jan 2026 | Originally published
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