Autonomic Neuropathy

Authored by , Reviewed by Dr Hayley Willacy | Last edited | Meets Patient’s editorial guidelines

This article is for Medical Professionals

Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK and European Guidelines. You may find the Diabetic Neuropathy article more useful, or one of our other health articles.


Treatment of almost all medical conditions has been affected by the COVID-19 pandemic. NICE has issued rapid update guidelines in relation to many of these. This guidance is changing frequently. Please visit https://www.nice.org.uk/covid-19 to see if there is temporary guidance issued by NICE in relation to the management of this condition, which may vary from the information given below.

Autonomic neuropathy affects the autonomic neurons of either or both of the parasympathetic and sympathetic nervous systems. They are usually accompanied by somatic neuropathy but can be autonomic only. Autonomic testing should be considered in the evaluation of patients with polyneuropathy to document autonomic nervous system dysfunction[1].

Several syndromes and diseases exhibit autonomic neuropathies and there is a wide variety of clinical features and presentations[2]. In some patients the features are subclinical, whereas in others the dysfunction leads to significant disability. It is important to recognise and correctly diagnose autonomic neuropathy because successful treatments and management can be offered.

As might be expected, various pathophysiological processes are involved, depending on the particular cause. Although loss of somatic C fibres is associated with autonomic deficits, there is now known to be a more selective involvement of fibres in some conditions. Somatic and autonomic C fibre involvement is found in diabetic neuropathies[4]. The exact mechanism has not been worked out for all conditions and causes. However, the following have been identified and may be involved:

  • Genetic disorders such as dopamine-beta-hydroxylase deficiency.
  • Accumulation of toxins.
  • Autoantibodies. For example[5]:
    • Autonomic ganglionic acetylcholine receptor antibody (pandysautonomia).
    • Ganglionic receptor antibodies (postural orthostatic tachycardia syndrome).
    • Ganglioside autoantibodies (Guillain-Barré syndrome).
    • Antibodies to presynaptic channels (Eaton-Lambert syndrome).
    • Antineuronal antibodies (coeliac disease, paraneoplastic autonomic neuropathy).
  • Prevention of presynaptic acetylcholine release (botulism)[6].
  • Accumulation of toxic metabolites (for example, in liver disease).
  • Postganglionic abnormalities (connective tissue diseases, systemic lupus erythematosus (SLE), rheumatoid arthritis)[7].
  • Accumulation of glycolipids (Anderson-Fabry disease).

There is a long list of causes including hereditary and acquired conditions[8]. The full spectrum includes:

In general, these can occur in men and women at any age, but the epidemiology will depend on the particular cause. Some causes are very rare. However, one of the most common causes of autonomic neuropathy is likely to be diabetes mellitus. Progressive autonomic failure usually becomes apparent in the sixth decade of life. Typically it manifests with genitourinary symptoms and orthostatic hypotension but without somatic symptoms.

Autonomic nervous system dysfunction may present with a variety of symptoms. Orthostatic intolerance (including orthostatic hypotension or tachycardia) and sweating abnormalities (increased or decreased sweating) are common problems[11].

History

Autonomic nerve fibres are affected in most symmetrical peripheral neuropathies; however, involvement is often subclinical or mild[8]. Usually the onset of symptoms is slow and insidious. Occasionally the onset can be acute and dramatic in the acute forms. Usually there is sympathetic and parasympathetic dysfunction. Orthostatic or postural hypotension is the most commonly recognised symptom, but there is a wide variety of other possible symptoms. A family history and drug history may also be important.

Possible symptoms of autonomic neuropathy

Sweating
There may be no sweating or reduced sweating (anhidrosis and hypohidrosis), but excessive sweating (or hyperhidrosis) can occur as a compensatory mechanism.

Temperature regulation
Hypothermia and hyperpyrexia can result from disruption of the various temperature regulatory mechanisms. Sweating, shivering and vasoactive reflexes can be affected.

Face

  • Pallor.
  • Reduced or absent sweating.

Vision

  • Blurring of vision.
  • Tunnel vision.
  • Light sensitivity.
  • Difficulty focusing.
  • Reduced lacrimation.
  • Gradual reduction of pupillary size.

Cardiovascular

  • Orthostatic hypotension (often associated with or exacerbated by eating, exercise and raised temperature).
  • Other orthostatic symptoms (for example, nausea, palpitations, light-headedness, tinnitus, shortness of breath).
  • Syncope (may occur with micturition, defecation).
  • Inability to stand without syncope (severe cases).
  • Arrhythmias.
  • Supine hypertension.
  • Loss of diurnal variation in blood pressure (BP).

Respiratory
In those with diabetes, reduced bronchoconstrictor reflexes have been detected (contributing to reduced responses to hypoxia).

Gastrointestinal

  • Constipation.
  • Diarrhoea.
  • Incontinence.
  • Dry mouth.
  • Disturbance of taste.

Sexual

  • Impotence.
  • Ejaculatory failure.
  • Female sexual dysfunction.

Feet

  • Burning sensation.
  • Hair loss.
  • Pruritus.
  • Dry skin.
  • Pale, cold feet.
  • Worsening of symptoms at night.

Examination[3]

There may be features on general examination which point to a specific disease. The neurological examination should be detailed and thorough, incorporating motor and sensory examination. There are a few specific techniques which can be used for certain specific autonomic abnormalities.

General examination

  • Stigmata of liver disease.
  • Skin conditions (for example, Lyme disease and leprosy).
  • Signs of connective tissue diseases (for example, rheumatoid arthritis, SLE, Sjögren's syndrome).
  • Features of unusual conditions (such as Anderson-Fabry disease and amyloidosis).

Neurological examination

  • Motor examination (power, tone, co-ordination and reflexes).
  • Sensory examination (all modalities including proprioception).
  • It is important to identify stocking pattern of sensory loss (concurrent somatic neuropathy).

More specific examination

Looking for signs of autonomic dysfunction:

Testing for abnormalities of BP regulation

  • Look for postural drop of systolic BP >20 mm Hg (lying and sitting) or >10 mm Hg with presyncopal symptoms[12].
  • Measure BP after isometric exercise (in the opposite arm). BP should increase by >16 mm Hg in the opposite arm.
  • Measure postprandial BPs to detect >20 mm Hg 20 minutes after meal (abnormal).
  • Detect >15 mm Hg diurnal variation of BP (suggests autonomic neuropathy).
  • Measure BP after hand immersion in ice cold water for one minute. Contralateral arm shows >10 mm Hg diastolic drop as normal response.
  • Detection of normal pulse variation with breathing (increases inspiration, decreases during expiration).
  • BP recovery after Valsalva manoeuvre[3].

Skin examination

  • Palms, soles and axillae (establish whether there is sweating).
  • Note whether there is skin shrivelling after prolonged immersion in water.

Eye examination

  • Pupil responses (to light and accommodation).
  • Look for Horner's syndrome.
  • Examine for effects of reduced eye secretions (cornea).

Mouth examination
Look for excessive dental decay (an effect of dry month).

Abdominal examination

Looking for an enlarged bladder.

Patients with Parkinson's disease can have autonomic dysfunction (constipation and urinary retention) but unlike peripheral autonomic neuropathies have extrapyramidal dysfunction (akinesia, tremor, rigidity). 

Non-invasive measures of cardiovascular parasympathetic function involve the assessment of heart rate variability. Measures of cardiovascular sympathetic function assess the blood pressure response to physiological stimuli.

Tilt-table testing, with or without pharmacological provocation, has become an important tool in the assessment of a predisposition to neurally mediated (vasovagal) syncope, postural tachycardia and orthostatic hypotension.

Distal, postganglionic, sympathetic cholinergic (sudomotor) function may be evaluated by provoking axon reflex mediated sweating. The thermoregulatory sweat test provides a non-localising measure of global pre-ganglionic and postganglionic sudomotor function[3].

The particular selection of tests is dependent on the clinical presentation but may include[13]:

  • FBC and differential.
  • Fasting blood glucose.
  • HIV testing.
  • Immunoelectrophoresis of blood and urine.
  • Plasma norepinephrine (supine and standing).
  • Porphyria investigations.
  • Genetic testing for inherited neuropathies.
  • Amyloid investigation.
  • Autoantibody assessment: antinuclear antibody, rheumatoid factor, anti-Ro/SS-A, anti-La/SS-B, antibodies to acetylcholine receptor, paraneoplastic antibodies-anti-Hu (type 1 anti-neuronal nuclear antibody (ANNA-1), Purkinje-cell cytoplasmic antibodies type 2 (PCA-2), collapsin response-mediator protein 5 (CRMP-5)). See also the separate Plasma Autoantibodies article.
  • ECG:
    • Variation in heart rate with respiration of fewer than 10 beats per minute is abnormal.
    • Measure beat-to-beat variation of R-R interval (with respiration and during Valsalva manoeuvre).
  • Nerve conduction studies (often normal, as affected fibres are small and not assessed by this or electromyogram (EMG) studies).
  • Cystometry (bladder pressures).
  • CSF examination (lumbar puncture):
    • Protein changes with dorsal root ganglia damage.
    • Changes of HIV or AIDS.
    • Changes consistent with paraneoplastic neuropathies (not specific).
  • Imaging studies:
    • Barium swallow.
    • Urodynamic studies (ultrasound may be employed).
    • Positron emission tomography (PET) scanning for cardiac sympathetic dysfunction (diabetes).
  • Vascular studies:
    • Doppler studies.
    • Infrared thermometry.
    • Skin blood flow measures (transcutaneous oxygenation, skin temperature).
  • Some more specific tests that have been suggested:
    • Sympathetic skin responses (using EMG equipment).
    • Quantitative sensory testing (comparison of sensory thresholds).
    • Thermoregulatory sweat test.
    • Quantitative sudomotor axon reflex test (tests thermoregulatory pathways).

There is a variety of diseases associated with autonomic neuropathy. This can be appreciated from the causal conditions listed above.

Management should start from initial diagnosis and incorporate patient education about the condition and implications for the patient. This may range from measures to prevent orthostatic hypotension to improvements in self-care (from hygiene to care of diabetes mellitus).

  • Treatment of the underlying cause.
  • Orthostatic hypotension: see also the separate Hypotension article.
  • Gastrointestinal dysfunction:
    • Gastroparesis in patients with diabetic autonomic neuropathy is improved by rigorous control of blood glucose. concentrations[14].
    • Eat small meals and eat often.
    • Lower the fat content of the diet.
    • Prokinetic agents for gastroparesis can be used (metoclopramide, domperidone and erythromycin). A jejunostomy tube may rarely be required.
    • Bowel hypomotility. This can be helped with:
      • Increased dietary fibre and an increase in fluid intake.
      • Use of stool softeners and/or an osmotic laxative.
      • Trying out a gluten-free diet and restriction of lactose.
      • Colestyramine, clonidine, somatostatin analogues, pancreatic enzyme supplements, and even antibiotics (such as metronidazole), which have been tried[8].
  • Genital autonomic neuropathy:
  • Autonomic dysfunction of the urinary tract:
    • Timed voiding schedules and bladder contractions increased by a Valsalva manoeuvre.
    • Clean intermittent self-catheterisation.
    • Cholinergic agonists (eg, bethanechol) have a limited role.
  • Hyperhidrosis:

Many complications exist. The most severe are:

  • Cardiac arrest, cardiac dysrhythmias, sudden cardiac death[15].
  • Blood pressure fluctuations and the risk of cerebral and cardiac ischaemia.

The prognosis is determined by the particular cause of the autonomic neuropathy. In most cases the course is one of gradual progression. In the case of diabetes mellitus the prognosis is improved with good control of diabetes. Other measures to halt progression may be applicable, such as abstinence from alcohol or by treatment of correctable syndromes.

Further reading and references

  • Lin YK, Fisher SJ, Pop-Busui R; Hypoglycemia unawareness and autonomic dysfunction in diabetes: Lessons learned and roles of diabetes technologies. J Diabetes Investig. 2020 Nov11(6):1388-1402. doi: 10.1111/jdi.13290. Epub 2020 Jul 7.

  • Khemani P, Mehdirad AA; Cardiovascular Disorders Mediated by Autonomic Nervous System Dysfunction. Cardiol Rev. 2020 Mar/Apr28(2):65-72. doi: 10.1097/CRD.0000000000000280.

  1. England JD, Gronseth GS, Franklin G, et al; Practice Parameter: evaluation of distal symmetric polyneuropathy: role of autonomic testing, nerve biopsy, and skin biopsy (an evidence-based review). Report of the American Academy of Neurology, American Association of Neuromuscular and Electrodiagnostic Medicine, and American Academy of Physical Medicine and Rehabilitation. Neurology. 2009 Jan 1372(2):177-84. doi: 10.1212/01.wnl.0000336345.70511.0f. Epub 2008 Dec 3.

  2. Low PA, Vernino S, Suarez G; Autonomic dysfunction in peripheral nerve disease. Muscle Nerve. 2003 Jun27(6):646-61.

  3. Sanchez-Manso JC, Muppidi V, Varacallo M; Autonomic Dysfunction. StatPearls, 2020.

  4. Dull MM, Riegel K, Tappenbeck J, et al; Methylglyoxal causes pain and hyperalgesia in human through C-fiber activation. Pain. 2019 Nov160(11):2497-2507. doi: 10.1097/j.pain.0000000000001644.

  5. Sandroni P, Low PA; Other autonomic neuropathies associated with ganglionic antibody. Auton Neurosci. 2009 Mar 12146(1-2):13-7. doi: 10.1016/j.autneu.2008.10.022. Epub 2008 Dec 4.

  6. Nigam PK, Nigam A; Botulinum toxin. Indian J Dermatol. 201055(1):8-14. doi: 10.4103/0019-5154.60343.

  7. Imamura M, Mukaino A, Takamatsu K, et al; Ganglionic Acetylcholine Receptor Antibodies and Autonomic Dysfunction in Autoimmune Rheumatic Diseases. Int J Mol Sci. 2020 Feb 1621(4). pii: ijms21041332. doi: 10.3390/ijms21041332.

  8. Freeman R; Autonomic peripheral neuropathy. Lancet. 2005 Apr 2-8365(9466):1259-70.

  9. Vinik AI, Erbas T; Diabetic autonomic neuropathy. Handb Clin Neurol. 2013117:279-94. doi: 10.1016/B978-0-444-53491-0.00022-5.

  10. Thieben MJ, Sandroni P, Sletten DM, et al; Postural orthostatic tachycardia syndrome: the Mayo clinic experience. Mayo Clin Proc. 2007 Mar82(3):308-13.

  11. Klein CM; Evaluation and management of autonomic nervous system disorders. Semin Neurol. 2008 Apr28(2):195-204. doi: 10.1055/s-2008-1062263.

  12. Briasoulis A, Silver A, Yano Y, et al; Orthostatic hypotension associated with baroreceptor dysfunction: treatment approaches. J Clin Hypertens (Greenwich). 2014 Feb16(2):141-8. doi: 10.1111/jch.12258.

  13. Low PA; Laboratory evaluation of autonomic function. Suppl Clin Neurophysiol. 200457:358-68.

  14. Krishnasamy S, Abell TL; Diabetic Gastroparesis: Principles and Current Trends in Management. Diabetes Ther. 2018 Jul9(Suppl 1):1-42. doi: 10.1007/s13300-018-0454-9. Epub 2018 Jun 22.

  15. Goldberger JJ, Arora R, Buckley U, et al; Autonomic Nervous System Dysfunction: JACC Focus Seminar. J Am Coll Cardiol. 2019 Mar 1973(10):1189-1206. doi: 10.1016/j.jacc.2018.12.064.

I've found several forums where there have been posts from people experiencing this disconcerting feeling of an internal quivering or vibration but none of them are current, so I wanted to see if...

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