Can I take Amlodipine/ valsartan and Atenolol together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
Taking these medicines together can cause your blood pressure to drop too low (hypotension) or your heart rate to slow down too much (bradycardia). You might feel dizzy, lightheaded, faint, or unusually tired.
In this article:
Continue reading below
Why this happens
All three medicines work to lower blood pressure and reduce the workload on your heart, but they do it in different ways. Amlodipine relaxes blood vessels, valsartan blocks a hormone that narrows vessels, and atenolol slows the heart rate. When combined, their effects add together, which can sometimes be too powerful.
What you should do
You can take these together if they have been prescribed by your doctor, but you should monitor your blood pressure and heart rate regularly at home. Be careful when standing up quickly from a sitting or lying position. If you feel very dizzy, faint, or notice a very slow pulse, contact your doctor.
Continue reading below
Important precautions
Asthma or COPD
Do not take this medicine if you have asthma, wheezing, or chronic obstructive pulmonary disease (COPD). It can cause a severe, potentially life-threatening narrowing of the airways.
Food and drink warnings
Alcohol
Drinking alcohol while taking these blood pressure medicines can cause an additive effect, making you feel dizzy, lightheaded, or faint, especially when standing up. It is best to keep alcohol intake within recommended limits and see how the medicine affects you first.
Orange Juice and Apple Juice
Drinking large amounts of orange or apple juice may reduce the amount of atenolol absorbed by your body, potentially making it less effective. It is best to avoid drinking large quantities of these juices at the same time as taking your tablet.
Continue reading below
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Atorvastatin and Flecainide together?
There is no known direct interaction between atorvastatin and flecainide. Both medications can be taken together safely in most cases.

Treatment and medication
Can I take Esomeprazole and Vitamin c together?
Esomeprazole may slightly reduce how much Vitamin C your body absorbs, but this is generally not a cause for concern for most people.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.