Can I take Atorvastatin and Furosemide together?

Why this happens

These drugs work in different ways and are processed by different pathways in the body. Atorvastatin works in the liver to lower cholesterol, while furosemide works in the kidneys to remove excess fluid. They do not significantly change how the other is absorbed or cleared from the system.

What you should do

You can safely take these medicines together as prescribed. Ensure you attend your regular blood tests to check your cholesterol, liver function, and kidney health. If you experience any unexplained muscle pain, tenderness, or weakness, contact your doctor.

Important precautions

Pregnancy

You must not take atorvastatin if you are pregnant or planning to become pregnant, as it can cause serious harm to an unborn baby. Use effective contraception while taking this medicine.

Muscle disorders - atorvastatin

Seek immediate medical advice if you experience unexplained muscle pain, tenderness, or weakness. In rare cases, this can lead to a serious condition called rhabdomyolysis which causes kidney damage.

Dehydration and electrolyte imbalance

Furosemide is a powerful diuretic. You must report signs of severe dehydration or electrolyte loss, such as extreme thirst, confusion, or severe muscle cramps, to your doctor.

Food and drink warnings

Grapefruit juice

Grapefruit juice contains compounds that can increase the level of atorvastatin in your blood. This may increase your risk of side effects, such as muscle pain or damage. Avoid drinking large quantities (more than 1.2 litres per day), though it is safest to avoid it altogether or keep intake to very small amounts.

Alcohol

While alcohol does not directly interact with atorvastatin, drinking large amounts of alcohol can increase the risk of liver problems and muscle side effects. It is best to keep your intake within the recommended limits (no more than 14 units per week).

Liquorice (Natural)

Avoid consuming large amounts of natural liquorice. It can cause your body to lose potassium, which, when combined with furosemide (a diuretic that also removes potassium), can lead to dangerously low potassium levels.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.