Can I take St john's wort and Vitamin b12 together?

Why this happens

St John's Wort is known to affect the liver enzymes (specifically CYP3A4) and a transport protein (P-glycoprotein) that clear many medicines from the body. However, Vitamin B12 (cobalamin) is a water-soluble vitamin that is absorbed and processed by the body through different pathways that are not affected by these enzymes.

What you should do

You can continue to take both as directed. However, if you are taking St John's Wort, you should always check with a pharmacist or doctor before starting any other new medications, as it interacts with many prescription drugs (such as the contraceptive pill, blood thinners, and antidepressants).

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.