Can I take Fluanxol and Pregabalin together?

Why this happens

Both medicines work by slowing down activity in the central nervous system (the brain and nerves). When used together, their sedative effects are added together (an additive effect), making the side effects much stronger than if you took either medicine alone.

What you should do

Use this combination with caution. Avoid driving, operating heavy machinery, or performing tasks that require you to be alert until you know how these medicines affect you. Do not drink alcohol while taking these medicines, as it will make the sleepiness much worse. If you feel extremely drowsy or have difficulty breathing, contact your doctor immediately.

Important precautions

Mental health disorders

Pregabalin can cause suicidal thoughts or an urge to self-harm. You must seek medical help immediately if your mood changes or you have thoughts of hurting yourself.

Pregnancy

Pregabalin must not be used during pregnancy unless specifically advised by a specialist, as it may increase the risk of birth defects. Effective contraception must be used during treatment.

Parkinson's disease

Fluanxol can significantly worsen the symptoms of Parkinson's disease and should generally be avoided.

Heart rhythm disorders (Long QT syndrome)

Fluanxol can affect your heart rhythm. You must tell your doctor if you have a history of heart rhythm problems or are taking other medicines that affect the heart.

History of drug or alcohol misuse

Pregabalin has a high risk of dependence and addiction. You should only take it exactly as prescribed and be aware that it can be misused.

Driving and operating machinery

Both medicines can cause significant drowsiness and blurred vision. Do not drive or use tools until you are certain you are not affected, as your reaction speeds will be reduced.

Respiratory depression

Pregabalin can cause severe breathing problems, especially if you already have lung disease or if you take it with other medicines that cause drowsiness or contain opioids.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol while taking these medicines. Both Fluanxol and pregabalin cause drowsiness and dizziness; alcohol will significantly increase these effects, making you more likely to have an accident or fall. Combining alcohol with Fluanxol also increases the risk of liver damage. They can also increase the risk of breathing problems.

Caffeine (Coffee, Tea, Energy Drinks)

Caffeine can interfere with how Fluanxol works. High amounts of caffeine may reduce the effectiveness of the medicine or worsen symptoms of restlessness and anxiety. Try to keep your caffeine intake consistent and moderate.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.