Can I take Clarithromycin and Paracetamol together?

Why this happens

These two drugs are processed by different pathways in the body. Clarithromycin is primarily broken down by a specific liver enzyme (CYP3A4) which it also inhibits, while paracetamol is processed through different liver pathways (glucuronidation and sulfation). Because they do not compete for the same 'machinery' in the liver, they do not interfere with each other.

What you should do

You can take paracetamol while you are on a course of clarithromycin. Always follow the dosage instructions on the packet for paracetamol and complete the full course of your antibiotic as prescribed by your doctor. If you feel unwell or develop a rash, contact your healthcare provider.

Important precautions

Heart rhythm disorders (Long QT syndrome)

Clarithromycin can cause serious heart rhythm problems. You must not take it if you have a history of 'Long QT syndrome' or are taking other medicines that affect your heart rate.

Liver disease or chronic alcohol use

If you have liver problems or drink large amounts of alcohol regularly, you are at a much higher risk of fatal liver damage from paracetamol, even at standard doses.

Food and drink warnings

Alcohol

While there is no direct interaction, both clarithromycin and alcohol can cause side effects like nausea, dizziness, or stomach upset. It is generally best to avoid alcohol until you have finished your course and feel better.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.