Can I take Mirtazapine and Nortriptyline together?

Why this happens

Both medicines increase the levels of a chemical called serotonin in the brain. If levels get too high, it can cause serious side effects. Additionally, both drugs have 'anticholinergic' and sedative effects, which means their side effects (like sleepiness and dry mouth) can add together and become more intense.

What you should do

You should only take these two medicines together if specifically prescribed by a specialist who is monitoring you closely. Seek immediate medical help if you experience high fever, agitation, shivering, muscle stiffness, or a rapid heartbeat. Avoid driving or operating machinery until you know how this combination affects you.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.