Can I take Mirtazapine and Pericyazine together?

Why this happens

Both drugs have 'sedating' effects on the brain and nervous system, which add together when taken together. They also both have 'anticholinergic' effects (blocking certain nerve signals) and can both affect the electrical activity of the heart (prolonging the QT interval).

Speak to your doctor before taking these together. If your doctor has prescribed both, be aware that you may feel more tired than usual. Do not drive or operate machinery until you know how these medicines affect you. Seek medical help immediately if you feel your heart racing, experience fainting, or feel very dizzy.

Blood disorders (Agranulocytosis)

Contact your doctor immediately if you develop a fever, sore throat, mouth ulcers, or other signs of infection. This medicine can rarely cause a serious drop in white blood cell counts.

Temperature regulation and Heatstroke

This medicine makes you more prone to heatstroke. Avoid prolonged exposure to high temperatures and ensure you stay hydrated, as it can interfere with your body's ability to sweat and cool down.

Eye health (Glaucoma)

Do not take this medicine if you have narrow-angle glaucoma, as it can significantly increase the pressure inside your eye and lead to sudden vision loss.

Alcohol

You should avoid drinking alcohol while taking these medicines. Both mirtazapine and pericyazine can make you feel very sleepy, and alcohol will significantly increase this effect. It can also affect your coordination and ability to think clearly.

Caffeine (Coffee, tea, energy drinks)

Large amounts of caffeine may interfere with the effects of pericyazine. Try to keep your intake of tea, coffee, and caffeinated soft drinks consistent and moderate.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.