Can I take Paracetamol and Amoxicillin together?

You can take paracetamol and amoxicillin together as they are processed by the body in different ways and do not interfere with each other's absorption, metabolism, or effectiveness.

Paracetamol is primarily broken down by the liver, while amoxicillin is mainly cleared through the kidneys.

How to take paracetamol and amoxicillin together

• Always follow the dosage instructions on the packet or those provided by your doctor or pharmacist.

• If you are taking amoxicillin for an infection, make sure you finish the entire course even if you start to feel better.

Important precautions

Liver disease

You must not exceed the maximum dose of 4g (eight 500mg tablets) of paracetamol in 24 hours. Taking even a small amount more than the recommended dose can cause serious, permanent liver damage. Check all other medicines (like cold and flu remedies) to ensure they do not also contain paracetamol.

Penicillin allergy

Do not take amoxicillin if you have ever had an allergic reaction to penicillin or cephalosporin antibiotics. A reaction can be life-threatening.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol when taking paracetamol. Combining alcohol and paracetamol increases the risk of serious liver damage.

It is best to avoid or strictly limit alcohol while taking amoxicillin. While there is no direct chemical interaction, alcohol can dehydrate you and interfere with your sleep, which may slow down your recovery from infection. Additionally, both alcohol and amoxicillin can cause stomach upset or nausea, and combining them may make these side effects worse.

Food (General)

Amoxicillin can be taken with or without food. However, taking it at the start of a meal may help to reduce the risk of stomach upset or digestive side effects.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.