Can I take Paracetamol and Quinine together?

Why this happens

These two medicines are processed by different pathways in the liver and do not interfere with how the other is absorbed, broken down, or removed from the body. They also work on different systems in the body and do not have overlapping side effects.

You can take paracetamol and quinine together. Always follow the dosage instructions on the packet or as prescribed by your doctor. If you experience unusual side effects like ringing in the ears (tinnitus) or skin rashes, contact your doctor.

Liver health and dosing safety

Never exceed the maximum dose of 8 tablets (500mg each) of paracetamol in 24 hours. Taking too much can cause serious, permanent liver damage that may not show symptoms for several days. Check all other medicines (like cold and flu remedies) to ensure they do not also contain paracetamol.

Heart rhythm disorders (e.g. Long QT syndrome)

Quinine can cause serious, potentially life-threatening heart rhythm problems. Do not take this medicine if you have a history of heart rhythm issues or are taking other medicines that affect your heart rate.

Thrombocytopenia (low blood platelets)

Quinine can cause a dangerous drop in blood platelets. Seek urgent medical help if you notice unexplained bruising, nosebleeds, or purple spots on your skin.

Tinnitus (ringing in the ears) or optic neuritis

Stop taking quinine immediately and seek medical advice if you experience any changes to your hearing (such as ringing) or any sudden changes to your vision.

Alcohol

It is best to avoid or strictly limit alcohol when taking paracetamol. Combining alcohol and paracetamol increases the risk of serious liver damage.

It is best to avoid or strictly limit alcohol while taking quinine. Both alcohol and quinine can cause dizziness or blurred vision; combining them can make these effects worse and increase the risk of falls or accidents.

Grapefruit juice

Avoid drinking grapefruit juice while taking quinine. Grapefruit juice can increase the amount of quinine in your blood, which makes side effects more likely and can potentially lead to dangerous heart rhythm problems.

Tonic water

Tonic water contains small amounts of quinine. While the levels are low, consuming large amounts of tonic water alongside your medication could potentially increase the risk of side effects.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.