Can I take Pregabalin and Vitamin D together?

Why this happens

Pregabalin and vitamin D are processed by the body using different pathways. Pregabalin is mainly removed from the body by the kidneys and does not interfere with the liver enzymes that process vitamin D. Furthermore, they do not have overlapping side effects that would cause concern.

What you should do

You can continue to take both as prescribed. As with any supplement, it is always a good idea to inform your doctor or pharmacist about everything you are taking to ensure your records are up to date.

Important precautions

Mental health disorders

Pregabalin can cause suicidal thoughts or an urge to self-harm. You must seek medical help immediately if your mood changes or you have thoughts of hurting yourself.

Severe respiratory depression

Pregabalin can cause serious breathing problems, especially if you already have lung disease or if you take it with other sedating medicines like opioids. Seek emergency help if you experience slow, shallow, or difficult breathing.

Pregnancy

Pregabalin use during the first three months of pregnancy may increase the risk of birth defects. Effective contraception must be used during treatment.

Drug dependence and withdrawal

Pregabalin carries a risk of dependence and addiction. Do not stop taking it suddenly, as this can cause severe withdrawal symptoms such as seizures or anxiety.

Hypercalcaemia (high blood calcium)

Do not take vitamin D if you have high levels of calcium in your blood or urine, as it can lead to serious kidney damage and heart rhythm problems.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol while taking pregabalin. Combining alcohol with this medicine can significantly increase side effects such as extreme sleepiness, dizziness, and blurred vision. It can also increase the risk of breathing problems.

High-fat meals

Vitamin D is a fat-soluble vitamin. It is best absorbed by your body when taken with a meal that contains some fat (such as eggs, avocado, or nuts).

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.