Ketoprofen for pain and inflammation

About ketoprofen

What is ketoprofen used for?

Ketoprofen is an anti-inflammatory painkiller that eases pain and swelling (inflammation) in conditions like arthritis, sprains and strains, and gout, and it may also be used as pain relief for period (menstrual) pain, and after surgical operations.

How does ketoprofen work?

Ketoprofen works by blocking the effect of natural chemicals called cyclo-oxygenase (COX) enzymes. These enzymes help to make other chemicals, called prostaglandins, in the body.

Some prostaglandins are produced at sites of injury or damage, and cause pain and inflammation. By blocking the effect of COX enzymes, fewer prostaglandins are produced, which means pain and inflammation are eased.

What is ketoprofen available as?

Ketoprofen is also available as a gel which can be applied directly to your skin to help relieve muscle and joint pain. There is more information about this in a separate leaflet called Ketoprofen gel for pain relief.

Side effects of ketoprofen

Common side effects of ketoprofen are:

• Indigestion.

• Heartburn.

• Tummy (abdominal) discomfort.

• Feeling sick (nausea) or being sick (vomiting).

• Constipation.

• Diarrhoea.

• Wind.

• Headache.

• Feeling dizzy or sleepy.

• Itchy rash.

• Swollen feet.

You will find a full list in the manufacturer's information leaflet supplied with your medicine.

The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

How to manage ketoprofen side effects

Who should not take ketoprofen?

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking ketoprofen, it is important that your doctor knows:

• If you have asthma or any other allergic disorder.

• If you have ever had a stomach or duodenal ulcer, or if you have an inflammatory bowel disorder such as Crohn's disease or ulcerative colitis.

• If you are pregnant, trying for a baby, or breastfeeding.

• If you have any problems with the way your liver works, or if you have any problems with the way your kidneys work.

• If you have a heart condition or a problem with your blood vessels or circulation.

• If you have high blood pressure (hypertension).

• If you have any blood clotting problems.

• If you have diabetes (diabetes mellitus) or high cholesterol levels.

• If you have a connective tissue disorder such as systemic lupus erythematosus. This is an inflammatory condition which is also called lupus or SLE.

• If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.

• If you have ever had an allergic reaction to any other NSAID (such as aspirin, ibuprofen, diclofenac, and indometacin), or to any other medicine.

How to take ketoprofen

• Before starting ketoprofen, read the patient information leaflet inside the pack. It explains how the capsules work and lists possible side effects.

• Take ketoprofen exactly as prescribed by your doctor. Prolonged-release capsules are taken once a day and come in 100 mg or 200 mg strengths.

• Take the capsule with food or just after a meal. Swallow it whole and do not chew or open it.

• Try to take your dose at the same time each day to help you remember.

• If you miss a dose, take it as soon as you remember unless it is the next day. Do not take two doses at the same time.

Getting the most from your treatment

• Your doctor will prescribe the lowest effective dose for the shortest possible time to reduce side effects. If you need long-term treatment, you may also be given medicine to protect your stomach.

• Keep regular appointments with your doctor so they can check your progress, especially if you are taking ketoprofen long term.

• If you are taking ketoprofen for gout and your symptoms have not improved after seven days, contact your doctor.

• If you have asthma, ketoprofen can sometimes worsen breathing symptoms. Stop taking it and see your doctor if this happens.

• Long-term use of some anti-inflammatory painkillers can slightly increase the risk of heart and circulation problems. Do not take more than the prescribed dose.

• Check with a pharmacist before taking any other medicines, including cold and flu remedies, as some contain anti-inflammatory painkillers.

• Tell your doctor, dentist, or surgeon about all the medicines you are taking before any treatment or operation.

How to store ketoprofen

• Keep all medicines out of the reach and sight of children.

• Store in a cool, dry place, away from direct heat and light.

Important information about all medicines

Frequently asked questions

How long does ketoprofen take to work?

Ketoprofen typically starts to relieve pain and inflammation within 1-2 hours of taking it. For some conditions, it may take a few days to feel the full effects, especially with long-term use.

Is it safe to take ketoprofen during pregnancy?

Ketoprofen is generally not recommended during pregnancy, particularly in the third trimester, as it may harm the baby. Always consult your doctor before taking any medication while pregnant.

Can I drink alcohol with ketoprofen?

It is best to avoid or limit alcohol while taking ketoprofen, as it can increase the risk of stomach irritation or bleeding. Drinking alcohol may also make side effects like dizziness more likely.

Is ketoprofen the same as ibuprofen?

No, ketoprofen and ibuprofen are not the same, although they are both anti-inflammatory painkillers. Ketoprofen is generally considered stronger, which means it may be more effective but can also cause more side effects.