Tramadol for pain relief
Marol Zamadol, Zydol
Peer reviewed by Dr Colin Tidy, MRCGPLast updated by Michael Stewart, MRPharmSLast updated 17 Feb 2023
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
This medicine is an opioid painkiller. There is a serious risk of addiction when taking this medicine, especially if used long-term. The Medicines and Healthcare products Regulatory Agency (MHRA) has issued new guidance for people prescribed an opioid painkiller. If you have any questions or concerns about taking opioids safely please speak with your doctor or a pharmacist.
Tramadol is prescribed to treat moderate to severe pain.
You may be prescribed it to take regularly, or only when it is needed for pain relief.
The most common side effects of tramadol are feeling sick (nausea) and feeling dizzy.
In this article:
Continue reading below
About tramadol
Type of medicine | Strong opioid painkiller |
Used for | Pain relief in adults and in children over 12 years of age |
Also called | Brimisol®; Marol®; Maxitram®; Tilodol®; Tradorec®; Tramquel®; Tramulief®; Zamadol®; Zydol®; |
Available as | Capsule, soluble tablet, orodispersible tablet (dissolves in the mouth), modified-release tablets and capsules, oral drops, and injection |
What is tramadol used for?
Tramadol is a strong opioid painkiller that is used to treat severe pain. It works on your nervous system and brain to reduce the amount of pain you feel.
Types of tramadol
Tramadol comes in different forms, strengths, and brands. Some types work quickly to relieve pain. Others release the medicine slowly over several hours to give more even, long-lasting pain relief.
Slow-release tramadol is often called modified-release and may have 'XL', 'SR', or '24-hour' in the name.
Continue reading below
Side effects of tramadol
Common side effects of tramadol include:
Feeling dizzy.
Feeling tired or sleepy.
Feeling sick.
Being sick (vomiting).
Constipation.
Dry mouth.
Less common side effects of include:
Headache.
Diarrhoea.
Itchy rash.
Sweating.
You will find a full list in the manufacturer's information leaflet supplied with your medicine.
The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any side effects continue or become troublesome.
How to manage tramadol side effects
Common tramadol side effects (these affect around 1 in 10 people) | What can I do if I experience this? |
Feeling dizzy, tired or sleepy | If this happens, do not drive and do not use tools or machines. Do not drink alcohol |
Feeling sick or being sick | Stick to simple meals - avoid rich or spicy foods |
Constipation | Eat a well-balanced diet and drink plenty of water each day. If this continues to be a problem, speak with your doctor |
Dry mouth | Try chewing sugar-free gum or sucking sugar-free sweets |
Less common side effects include: headache, diarrhoea, itchy rash, and sweating | If any of these become troublesome, speak with your doctor |
Important: people taking opioid medicines, and their family and friends, should be aware of the risk of accidental overdose and know when to seek medical help. The risk is higher if you also take other medicines that make you feel drowsy.
Signs you have taken too much medicine include:
Feeling very sleepy or dizzy.
Feeling sick or being sick.
Breathing difficulties.
Loss of consciousness.
If you have taken more tramadol than you should or someone else accidentally swallows your medication, call for an ambulance and tell them the name of your medicine.
If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.
Continue reading below
Who should not take tramadol?
Some medicines are not suitable for people with certain conditions. Before taking tramadol it is important that your doctor knows:
If you are pregnant, trying for a baby or breastfeeding.
If you have liver or kidney problems.
If you have prostate problems or any difficulties passing urine.
If you have any breathing problems, such as asthma or chronic obstructive pulmonary disease (COPD), or a sleep-related breathing problem.
If you have been told you have low blood pressure (hypotension).
If you have any problems with your thyroid or adrenal glands.
If you have epilepsy.
If you have a problem with your bile duct.
If you have been constipated for more than a week or have an inflammatory bowel problem.
If you have a condition causing muscle weakness, called myasthenia gravis.
If you have recently had a severe head injury.
If you have ever been dependent on drugs or alcohol.
If you have ever had an allergic reaction to a medicine.
If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
How to take tramadol
Take tramadol exactly as prescribed by your doctor. You may be told to take it regularly or only when needed.
Quick-acting tablets or capsules are usually taken every 4-6 hours.
Modified-release tramadol is taken once daily or twice daily (12 hours apart), depending on the product.
Do not take more than 400 mg in 24 hours.
Swallow modified-release tablets or capsules whole with water. Do not break, crush, or chew them unless the label says otherwise.
You can take tramadol with or without food.
If you miss a dose, check the leaflet for advice. Do not take two doses together to make up for a missed dose.
Getting the most from your treatment
Ask your doctor about alcohol. You may be advised not to drink while taking tramadol, as alcohol can increase side effects like dizziness and sleepiness.
Tramadol can affect driving. Do not drive if you feel drowsy, dizzy, or your reactions are slowed. It is an offence to drive if your ability is impaired.
If you do drive, carry proof that tramadol has been prescribed for you, such as a prescription slip or patient leaflet.
Tramadol comes in different brands and strengths. Check each prescription to make sure it is what you expect, and ask your pharmacist if you are unsure.
Tell healthcare professionals, including dentists, that you are taking tramadol before any treatment or surgery.
Check with a pharmacist before taking any other medicines, including those bought without a prescription. Some medicines can increase tramadol’s side effects.
If travelling abroad, carry a letter from your doctor, as tramadol is a controlled medicine and may be restricted in some countries.
Only take tramadol for as long as prescribed. Taking it for longer can lead to dependence.
Stopping tramadol suddenly can cause withdrawal symptoms, such as restlessness or irritability. Speak to your doctor or pharmacist if you have concerns.
How to store tramadol
Keep all medicines out of the reach and sight of children.
Store in a cool, dry place, away from direct heat and light.
Important information about all medicines
Important information about all medicines
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine ask your pharmacist.
Report side effects to a medicine or vaccine
If you experience side effects, you can report them online through the Yellow Card website.
Frequently asked questions
How long does it take for tramadol to work?
Quick-acting tramadol usually starts to work within 30 to 60 minutes, with pain relief typically lasting 4-6 hours. Modified-release tramadol may take 1-2 days to work but provides longer-lasting pain relief when taken regularly.
Can you drink alcohol with tramadol?
No, you should not drink alcohol while taking tramadol. Alcohol increases the risk of side effects such as drowsiness, dizziness, slowed breathing, and reduced alertness, which can be dangerous.
Is it safe to take tramadol during pregnancy?
Tramadol is not usually recommended during pregnancy as regular use may affect the baby and can cause withdrawal symptoms after birth.
Always let your doctor or midwife know if you are pregnant or planning a pregnancy before taking tramadol.
Can you take tramadol with paracetamol?
Yes, tramadol can be taken with paracetamol. They are often prescribed together to improve pain relief. Always follow dosing instructions and do not exceed the recommended dose of either medicine.
Is tramadol addictive?
Yes, tramadol can be addictive if taken regularly or for long periods. Your body can become dependent on it, and stopping suddenly may cause withdrawal symptoms such as restlessness or irritability.
For this reason, tramadol is usually prescribed at the lowest effective dose for the shortest time possible.
Further reading and references
- Manufacturer's PIL, Zydol® 50 mg capsules; Grunenthal Ltd. The electronic Medicines Compendium. Dated December 2021.
- Manufacturer's PIL, Zydol® SR 100 mg, 150 mg and 200 mg prolonged-release tablets; Grunenthal Ltd, The electronic Medicines Compendium. Dated December 2021.
- Manufacturer's PIL, Zamadol® SR 50 mg, 100 mg, 150 mg and 200 mg prolonged-release capsules; Mylan Products Ltd, The electronic Medicines Compendium. Dated November 2022.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Next review due: 16 Feb 2026
17 Feb 2023 | Latest version

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.