Steroid Injections

Last updated by Authored by Peer reviewed by Dr Doug McKechnie
Last updated Originally published Meets Patient’s editorial guidelines

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Steroid injections can be used for joint problems and rheumatoid arthritis. They can also be used for some conditions affecting soft tissues, like tendon inflammation or tennis elbow.

Steroid injections can be very effective but should be used with other treatments. There is also some evidence that steroid injections may be either completely ineffective or effective for just a relatively short period of time. Other treatments may include medicines for pain relief and physiotherapy, depending on the underlying condition. The side-effects from steroid injections are uncommon. However, the injected area may be sore for the first few days after the injection.

Steroid injections are anti-inflammatory injections that deliver a high dose of medicine (steroids) directly to the problem area in the body. Steroid injections can be used to reduce inflammation in joints and soft tissues, such as tendons or tennis elbow.

What are steroids?

Steroids are chemicals that occur naturally in the body. Steroid medicines can be used to reduce inflammation and are used to treat many different conditions, including arthritis. They are different to anabolic steroids that can be used to increase muscle size and strength.

Steroid injections may be used for people with rheumatoid arthritis or other causes of joint pain and swelling such as osteoarthritis, gout or frozen shoulder. Steroid injections may also be used for inflammation of soft tissues, such as:

A local steroid injection may be given to reduce inflammation and pain in a joint.

The main purpose of the steroid injection is to decrease pain and increase movement and use of the affected area. Steroid injections are usually well tolerated and much less likely than steroid tablets to cause serious side-effects. See the separate leaflet called Oral Steroids.

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Some GPs do steroid injections; they can also be done by certain specialists such as rheumatologists, orthopaedic surgeons, radiologists and specialist physiotherapists. Some clinicians may choose to do the injection using an ultrasound image to guide them. This helps ensure the steroid goes to the correct place. Most injections are quick and easy to perform but the injection must be given in a very clean (sterile) environment to prevent infection.

You should rest the injected joint for 1-2 days after the injection and avoid strenuous activity for five days. The steroid injection can be repeated if the first injection is effective. However, you should not have steroid injections in the same part of your body more than three times a year.

Short-acting steroid injections can give relief within hours and the benefit should last for at least a week. Longer-acting steroid injections may take about a week to become effective but can then be effective for two months or even longer. There is no evidence they provide any relief after six months.

A local anaesthetic may be combined with the steroid in the injection to reduce any discomfort of the injection. If the injected joint or soft tissue is painful after the injection then simple painkillers like paracetamol will help.

Side-effects of steroid injections are very unlikely but occasionally people notice a flare-up of pain in the injected area within the first 24 hours after the injection. This usually settles on its own within a couple of days but taking simple painkillers like paracetamol will help.

Other steroid-related side-effects are rare but may include:

  • Infection (If your joint becomes more painful and hot you should see your doctor immediately, especially if you feel unwell).
  • Allergic reactions.
  • Local bleeding.
  • Flushing of the skin.
  • Rupture of a tendon (if the injection is given directly into the tendon).
  • Excessively frequent, repeated injections into the same area can cause the bone, ligaments and tendons to weaken.
  • A rise in blood sugar levels for a few days after the injection may occur if you have diabetes.

Steroid injections can occasionally cause some thinning or changes in the colour of the skin at the injection site, especially if the injections are repeated. There is a possibility (at least in the opinion of some experts) that steroid injections may have a bad effect on soft tissue structures such as loss of cartilage tissue; however, the absolute evidence for this is currently small.

Steroids should not be injected when there is infection in the joint or area to be injected or anywhere else in the body. If a joint is already severely destroyed by arthritis, injections are not likely to give any benefit.

If you are likely to have replacement surgery within three months, steroid injection may make the risk of infection in the new joint higher.

If you have a potential bleeding problem or take blood-thinning (anticoagulant) medication (eg, warfarin), the steroid injections may cause bleeding at the site of the injection.

Frequent steroid injections (more often than once every three or four months) are not recommended because of the increased risk of weakening bone and soft tissues in the injected area.

You should also let your doctor know if you have high blood pressure, type 1 or type 2 diabetes, or any unhealed wounds.

Steroid injections can be part of your treatment. Depending on the condition being treated, a number of other medicines can be used in the treatment of inflammation of joints, tendons or other soft tissues. Physiotherapy and occupational therapy may also be helpful. Your practice nurse, GP or specialist will discuss your options with you.

How to use the Yellow Card Scheme

If you think you have had a side-effect to one of your medicines you can report this on the Yellow Card Scheme. You can do this online at

The Yellow Card Scheme is used to make pharmacists, doctors and nurses aware of any new side-effects that medicines or any other healthcare products may have caused. If you wish to report a side-effect, you will need to provide basic information about:

  • The side-effect.
  • The name of the medicine which you think caused it.
  • The person who had the side-effect.
  • Your contact details as the reporter of the side-effect.

It is helpful if you have your medication - and/or the leaflet that came with it - with you while you fill out the report.


Oral Steroids

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Further reading and references

  • Foster ZJ, Voss TT, Hatch J, et al; Corticosteroid Injections for Common Musculoskeletal Conditions. Am Fam Physician. 2015 Oct 1592(8):694-9.

  • Freire V, Bureau NJ; Injectable Corticosteroids: Take Precautions and Use Caution. Semin Musculoskelet Radiol. 2016 Nov20(5):401-408. doi: 10.1055/s-0036-1594286. Epub 2016 Dec 21.

  • Kim YM, Joo YB, Song JH; Preoperative intra-articular steroid injections within 3 months increase the risk of periprosthetic joint infection in total knee arthroplasty: a systematic review and meta-analysis. J Orthop Surg Res. 2023 Feb 2818(1):148. doi: 10.1186/s13018-023-03637-4.

  • Khan M, Bhandari M; Cochrane in CORR(R): Intra-articular Corticosteroid For Knee Osteoarthritis. Clin Orthop Relat Res. 2018 Jul476(7):1391-1392. doi: 10.1097/CORR.0000000000000358.

  • Challoumas D, Biddle M, McLean M, et al; Comparison of Treatments for Frozen Shoulder: A Systematic Review and Meta-analysis. JAMA Netw Open. 2020 Dec 13(12):e2029581. doi: 10.1001/jamanetworkopen.2020.29581.