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Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK and European Guidelines. You may find the Breathlessness and difficulty breathing article more useful, or one of our other health articles.

Synonym: dyspnoea

Breathlessness is the distressing sensation of a deficit between the body's demand for breathing and the ability of the respiratory system to satisfy that demand. Breathlessness can be classified by its speed of onset as1 :

  • Acute breathlessness: develops over minutes.

  • Subacute breathlessness: develops over hours or days.

  • Chronic breathlessness: develops over weeks or months.

Chronic refractory dyspnoea is defined as breathlessness daily for three months at rest or on minimal exertion where contributing causes have been treated maximally. Common causes include chronic obstructive pulmonary disease (COPD), heart failure, advanced cancer and interstitial lung diseases2 .

Physiologically, we are all aware of breathlessness when we exercise beyond our normal tolerance but pathologically it can occur with little or no exertion. Afferent sources for the sensation of breathlessness arise from receptors in the upper airway, lungs and chest wall as well as autonomic centres in the brain stem and motor cortex. It is almost always associated with fear and, when chronic, can be disabling and severely diminish quality of life3 .

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Approximately two thirds of cases of dyspnoea in adults are due to a pulmonary or cardiac disorder. In about a third of cases, diagnosis will be multifactorial4 .

Acute and subacute causes of breathlessness5

Cardiac causes

Pulmonary causes

Other causes of acute breathlessness

Chronic causes of breathlessness4

Cardiac causes

  • Left ventricular disease.

  • Heart valve disease (mitral and aortic stenosis).

  • Arrhythmias.

  • Pericardial disease.

Pulmonary causes

  • Asthma.

  • COPD.

  • Lung fibrosis.

  • Pleural effusion.

  • Emphysema.

  • Lung cancer.

  • Bronchiectasis.

  • COVID-19 (most cases follow a subacute course, with breathlessness developing over a few days; the pathology appears to involve a bilateral inflammatory reaction within the respiratory bronchioles)6 .

Other causes


Next to pain, breathlessness is the most common symptom for which patients seek help and relief from their doctor. Peak incidence of chronic dyspnoea occurs in the 55- to 69-year-old age bracket4 .


  • Duration of breathlessness and speed of onset, ie acute, chronic.

  • Timing of breathlessness - eg, diurnal variation with asthma.

  • Any known precipitating events - eg, trauma, palpitations, chest pain, exercise.

  • Any symptoms suggestive of COVID-19 infection - eg, a new continuous cough, loss or change of sense of taste or smell.

  • Past medical history - allergy, chest or cardiac disease, anxiety-related disorder.

  • Family history, especially heart disease.

  • Lifestyle/occupation - smoking history, occupation, pets, close contact with birds.

  • Drug exposure (beta-blockers, amiodarone, nitrofurantoin, methotrexate, heroin).


Try to quantify exercise tolerance (eg, breathlessness at rest, with talking, dressing, distance walked or number of stairs climbed). There are a number of simple scales to assess the severity of breathlessness - eg, the modified Medical Research Council (MRC) dyspnoea score7 :

  • Grade 0: not troubled by breathlessness except on strenuous exertion.

  • Grade 1: short of breath when hurrying on level ground or walking up a slight incline.

  • Grade 2: walks slower than contemporaries because of breathlessness, or has to stop for breath when walking at own pace.

  • Grade 3: stops for breath after walking about 100 metres or stops after a few minutes of walking on level ground.

  • Grade 4: too breathless to leave the house or breathless on dressing or undressing.

NB: there is no accepted gold standard for measuring breathlessness - unidimensional tools such as the above are recommended for assessing severity but multidimensional tools are required to capture the impact on quality of life8 .


Should include:


  • Patient distress, colour of skin and lips, cyanosis, clubbing, lymphadenopathy, tremor, flap.

  • Respiratory rate.

  • Pulse - rate, rhythm.

  • Height and weight (body mass index).


  • Trachea - central, deviated to one side.

  • Shape of chest - eg, kyphosis.

  • Movement of chest - symmetrical, asymmetrical.

  • Percussion note - eg, stony dull over a pleural effusion, hyper-resonant over a pneumothorax.

Auscultation of chest

  • Wheezing/rhonchi - eg, asthma, COPD, heart failure, bronchiolitis.

  • Crepitations - eg, pneumonia, bronchiectasis, fibrosis.

  • Stridor - eg, foreign body, acute epiglottitis, anaphylaxis, trauma.

  • No added sounds - eg, anaemia, pulmonary embolus, metabolic acidosis, neuromuscular causes.

  • Chest examination of a patient with COVID-19 infection may be normal and may be out of keeping with the distress and degree of breathlessness experienced by such a patient6 .

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These will be dependent on the findings of the history and examination but may include:

  • Lung function tests - eg, peak flow measurement, spirometry.

  • Pulse oximetry.

  • CXR.

  • Venous blood tests: FBC, brain natriuretic peptides (BNPs).

  • Nasal and saliva swabs for COVID-19.

  • Arterial blood gases.

  • ECG.

  • Imaging:

    • Echocardiogram.

    • High-resolution CT scan.

    • V/Q scan.

    • Radioallergosorbent test (RAST) measurement or skin prick testing to common aero-allergens.


This is dependent on the underlying cause.

In an acute situation, breathless individuals should be assessed rapidly and treated with high-flow oxygen (>60%) unless there is a known history of COPD, in addition to any specific therapy for the underlying condition. If unstable, transfer to hospital should be arranged as an emergency.

In the chronic situation, the underlying cause should be addressed and treated. Frequently breathlessness is a common end point of non-reversible disease and symptomatic relief should be sought instead.

Strategies for relieving breathlessness (of respiratory origin)

Reassure and educate the patient and caregivers to increase confidence in their ability to control and interpret symptoms.

Controlled breathing technique counteracts the fast, shallow, inefficient breathing associated with dyspnoea:

  • Control respiratory rate.

  • Use diaphragmatic breathing.

  • Relax shoulders and upper chest.

Sit upright: leaning forward when standing or nursing a bed-bound patient as upright as possible can help to relieve breathlessness.

Modify activities of daily living, lifestyle and expectations in line with disability but avoid excessive restrictions on activity.

Cognitive behavioural therapy (CBT) seeks to modify the patient's response to the symptom. Anxiety and panic can be reduced often by using techniques such as distraction or relaxation.

Pulmonary rehabilitation

Individuals with severe breathlessness become less active and their general fitness levels diminish, causing a cycle of worsening breathlessness with less and less physical exertion.

Supervised pulmonary rehabilitation programmes of exercise training have been shown to be beneficial in COPD, improving both dyspnoea and fatigue levels9 . Rehabilitation should not be neglected in a palliative setting10 .


Patients with severe respiratory disease tend to be cachectic and have such generalised muscle weakness that the work of breathing is extremely demanding. Addressing nutritional support with a dietician may be helpful.

Oxygen therapy

Ongoing or intermittent oxygen therapy via a face mask or nasal prongs may be of benefit in some selected cases. In chronic heart and lung disease, benefit is only evident where there is confirmed hypoxia or pulmonary hypertension. Consistent benefit of oxygen therapy in advanced lung cancer or cardiac failure patients has not been shown11 .

High-flow nasal oxygen is required to support COVID-19 patients with non-hypercapnic acute hypoxaemic respiratory failure. Protecting staff from the infectious aerosols arising from such treatment can prove challenging12 .

Partial ventilation support - continuous positive airway pressure (CPAP) can be used for several hours a day to rest chest muscles but is intrusive and of temporary benefit only.

Palliative care and symptomatic treatments11

  • Consider using a strong opioid in people who need symptomatic treatment of dyspnoea, especially those with shortness of breath who are near the end of life.

  • Anxiolytics can relieve dyspnoea by depressing hypoxic or hypercapnic ventilatory responses and altering the emotional response to dyspnoea.

  • Corticosteroids may be necessary in emergency situations involving airway obstruction but otherwise should ideally be initiated only by, or on the advice of, a specialist.

Further reading and references

  • Macnaughton J, Carel H; Breathing and Breathlessness in Clinic and Culture: Using Critical Medical Humanities to Bridge an Epistemic Gap
  • Oishi K, Matsunaga K, Harada M, et al; A New Dyspnea Evaluation System Focusing on Patients' Perceptions of Dyspnea and Their Living Disabilities: The Linkage between COPD and Frailty. J Clin Med. 2020 Nov 6;9(11). pii: jcm9113580. doi: 10.3390/jcm9113580.
  1. Breathlessness; NICE CKS, April 2020 (UK access only)
  2. Wiseman R, Rowett D, Allcroft P, et al; Chronic refractory dyspnoea--evidence based management. Aust Fam Physician. 2013 Mar;42(3):137-40.
  3. Ries AL; Impact of chronic obstructive pulmonary disease on quality of life: the role of dyspnea. Am J Med. 2006 Oct;119(10 Suppl 1):12-20.
  4. Karnani NG, Reisfield GM, Wilson GR; Evaluation of chronic dyspnea. Am Fam Physician. 2005 Apr 15;71(8):1529-37.
  5. Zoorob RJ, Campbell JS; Acute dyspnea in the office. Am Fam Physician. 2003 Nov 1;68(9):1803-10.
  6. Nie S, Han S, Ouyang H, et al; Coronavirus Disease 2019-related dyspnea cases difficult to interpret using chest computed tomography. Respir Med. 2020 Jun;167:105951. doi: 10.1016/j.rmed.2020.105951. Epub 2020 Apr 6.
  7. Launois C, Barbe C, Bertin E, et al; The modified Medical Research Council scale for the assessment of dyspnea in daily living in obesity: a pilot study. BMC Pulm Med. 2012 Oct 1;12:61. doi: 10.1186/1471-2466-12-61.
  8. Bausewein C, Booth S, Higginson IJ; Measurement of dyspnoea in the clinical rather than the research setting. Curr Opin Support Palliat Care. 2008 Jun;2(2):95-9.
  9. McCarthy B, Casey D, Devane D, et al; Pulmonary rehabilitation for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2015 Feb 23;(2):CD003793. doi: 10.1002/14651858.CD003793.pub3.
  10. Sachs S, Weinberg RL; Pulmonary rehabilitation for dyspnea in the palliative-care setting. Curr Opin Support Palliat Care. 2009 Jun;3(2):112-9.
  11. Palliative care - dyspnoea; NICE CKS, March 2021 (UK access only)
  12. Guy T, Creac'hcadec A, Ricordel C, et al; High-flow nasal oxygen: a safe, efficient treatment for COVID-19 patients not in an ICU. Eur Respir J. 2020 Nov 12;56(5). pii: 13993003.01154-2020. doi: 10.1183/13993003.01154-2020. Print 2020 Nov.

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The information on this page is written and peer reviewed by qualified clinicians.

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