Episcleritis and scleritis are inflammatory conditions which affect the eye. Both cause redness, but scleritis is much more serious than episcleritis.
What are episcleritis and scleritis?
Episcleritis affects only the episclera, which is the layer of the eye's surface lying directly between the clear membrane on the outside (the conjunctiva) and the firm white part beneath (the sclera). It causes redness and inflammation of the eye, often with discomfort and irritation but without other significant symptoms.
Scleritis affects the sclera and, sometimes, the deeper tissues of the eye. It is much less common than episcleritis. It causes a painful red eye and can affect vision, sometimes permanently.
What's the difference between episcleritis and scleritis?
Both episcleritis and scleritis are mainly seen in adults. They can initially look similar but they do not feel similar and they do not behave similarly. Both are slightly more common in women than in men. Both can be associated with other conditions such as rheumatoid arthritis and systemic lupus erythematosus (SLE), although this is more likely in the case of scleritis. Episcleritis does not cause scleritis, although scleritis can lead to associated episcleritis.
Episcleritis is a fairly common condition. It tends to come on quickly. It causes redness - often in a wedge shape over the white of the eye - and mild discomfort. It can occasionally be a little more painful than this and can cause inflamed bumps (nodules) to form on the surface of the eye. However, it is generally a mild condition with no serious consequences. It usually settles down by itself over a week or so with simple treatment. Episcleritis is often recurrent and can affect one or both eyes.
Scleritis is much less common. It tends to come on more slowly and affects the white layer (sclera) of the eye. It can spread to affect the adjacent layers around the sclera, including the episclera and the cornea. Scleritis tends to be very painful, causing a deep boring kind of pain in or around the eye. The eye is likely to be watery and sensitive to light and vision may be blurred. Scleritis can affect vision permanently. It may involve one or both eyes and is often associated with other inflammatory conditions such as rheumatoid arthritis.
The anatomy of the eye
The diagram shows the eye including the sclera. The episclera lies between the sclera and the conjunctiva.
What causes episcleritis and scleritis?
Episcleritis and scleritis are inflammatory conditions. It's not known what triggers the inflammation, which seems to start in the small blood vessels running on the surface of the eye. Both conditions are more likely to occur in people who have other inflammatory conditions, although this is particularly true of scleritis. Scleritis can occasionally be caused by infection with germs such as bacteria, viruses or, rarely, fungi.
Who develops episcleritis and scleritis?
Episcleritis is most common in the fourth to fifth decades in life. It is slightly more common in women than in men, and in people who have connective disease disease such as rheumatoid arthritis. About 40 people per 100,000 per year are thought to be affected. However, this is difficult to estimate accurately as because the condition is mild many do not seek medical advice.
Scleritis is less common, affecting only about 4 people per 100,000 per year. It affects a slightly older age group, usually the fourth to sixth decades of life. It is also slightly more common in women. It is more likely than episcleritis to be associated with an underlying inflammatory condition like rheumatoid arthritis.
What are the symptoms of episcleritis?
There are two types of episcleritis.
- The most common type is called diffuse episcleritis and it makes the surface of the eye evenly red, sometimes all over and sometimes in a wedge shape.
- The less common type is called nodular episcleritis. It comes on more slowly and causes inflamed swollen bumps or nodules in the episclera. It is more likely than diffuse episcleritis to be associated with an underlying inflammatory condition
- Both forms of episcleritis cause mild discomfort in the eye. The eyes may water a little and the eye may be a little tender when pressure is applied over the red area. However, vision is unaffected and painkillers are not generally needed.
- The diffuse type tends to be less painful than the nodular type.
- Episcleritis is often a recurrent condition, with episodes occurring typically every few months. Most attacks last 7-10 days, although in the case of nodular episcleritis this can be a little longer.
What are the symptoms of scleritis?
- Scleritis causes redness of the eye.
- It tends to come on more slowly than episcleritis
- As the redness develops the eye becomes very painful. This is a deep boring kind of pain inside and around the eye. It is typically much more severe than the discomfort of episcleritis.
- Sometimes the white of the eye has a bluish or purplish tinge.
- Vision may be blurred, the eye may be watery (although there is no discharge) and you may find it difficult to tolerate light (photophobia).
- There are several types of scleritis, depending on what part of the eye is affected and how inflamed the tissues are:
- Anterior scleritis is divided into:
- Non-necrotising type (most common). This is divided into:
- Diffuse anterior scleritis in which the eye is uniformly red.
- Nodular anterior scleritis in which tender nodules develop.
- Necrotising type:
- With inflammation: this is the most severe form of scleritis. It causes severe pain and tenderness and often causes permanent damage to the eye.
- Without inflammation: this rare condition is called scleromalacia perforans and is only seen in patients with long-standing rheumatoid arthritis. The eye is not red or painful but the sclera is gradually thinned.
- Posterior scleritis is rare and is also painful although your eye may not be red. Eye movements may be painful and there may be loss of vision.
What is the treatment for episcleritis?
- Episcleritis does not necessarily need any treatment. If symptoms are mild it will generally settle by itself.
- Lubricating eye drops or ointment may ease the discomfort whilst symptoms settle.
- If the eye is very uncomfortable, episcleritis may be treated with non-steroidal anti-inflammatory drugs (NSAIDs) in the form of eye drops.
- If this isn't enough (more likely in the nodular type) steroid eye drops are sometimes used, although only under the care of an eye specialist (ophthalmologist).
- If episcleritis does not settle over a week or so, or if worsening pain or altered vision develop, medical help should be sought in case this is, in fact, scleritis.
- If you have recurrent attacks of episcleritis your doctor will usually investigate you for underlying inflammatory diseases such as rheumatoid arthritis.
What is the treatment for scleritis?
- If you develop scleritis you will be urgently referred to an eye specialist (ophthalmologist). You will usually be seen on the same day.
- The management will depend on what type of scleritis this is and on its severity.
- The non-necrotising types are usually treated with oral NSAID medication. If this isn't effective, oral steroids are needed.
- Some doctors treat scleritis with injections of steroid medication into the sclera or around the eye.
- If these treatments don't work then immunosuppressant drugs such as methotrexate and cyclophosphamide may be used. They can take several weeks to work.
- Some of the new 'biological agents' such as rituximab can also be effective.
- Sometimes surgery is needed to treat the complications of scleritis.
- Necrotising scleritis is treated with oral steroids and immunosuppressants as early as possible.
- Scleromalacia perforans does not respond well to treatment - research continues to find the best way to manage this rare condition.
What are the possible complications of episcleritis and scleritis?
- Episcleritis does not usually lead to any complications.
- Scleritis can lead to permanent damage to the structure of the eye, including:
- Many of these conditions can permanently threaten sight, and some will require surgical treatment.
What is the long-term outlook (prognosis) for episcleritis and scleritis?
- Episcleritis does not usually have any significant long-term consequences unless it is associated with an underlying disease such as rheumatoid arthritis.
- The non-necrotising forms of scleritis do not usually permanently affect vision unless the patient goes on to develop uveitis.
- Necrotising scleritis with inflammation is the most severe and distressing form of scleritis. It is common for vision to be permanently affected.
- When either episcleritis or scleritis occur in association with an underlying condition like rheumatoid arthritis then their progress tends to mirror that of the underlying disease.
- Posterior scleritis is also associated with systemic disease and has a high likelihood of causing visual loss.
How do I prevent episcleritis and scleritis?
These inflammatory conditions cannot be directly prevented. For people with systemic inflammatory diseases such as rheumatoid arthritis, good control of the underlying disease is the best way of preventing this complication from arising.
Further reading and references
Episcleritis; Moorfields Hospital Accident and Emergency Department Patient Information Leaflet
Kopacz et al.; Scleromalacia Perforans: What We Know and What We Can Do. J Clinic Experiment Ophthalmol 2013, S2
Moorfields Manual of Ophthalmology
Hi, my name is Lucy. I'm 31 and I got diagnosed with posterior scleritis on the 1st of March 2013, I was 26. My life has changed a lot since then. I struggle to cope with the pain, I've not managed...Cornishmaid86
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