Chlorphenamine for allergies
Allerief, Hayleve, Piriton
Peer reviewed by Dr Colin Tidy, MRCGPLast updated by Michael Stewart, MRPharmSLast updated 17 Apr 2023
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
Chlorphenamine is an antihistamine. It eases allergic reactions.
The most common side effects are feeling tired or sleepy. If affected, do not drive and do not use tools or machines until you feel better.
Always make sure you follow the dosage directions on the label.
At a glance
Chlorphenamine is an antihistamine used to relieve allergy symptoms like hay fever and skin rashes.
It is available as tablets or oral liquid and can be bought without a prescription.
Common side effects include feeling dizzy or sleepy, blurred vision, and a dry mouth.
It usually starts working within 30 minutes to 1 hour.
Do not drive or use machinery if you feel drowsy after taking it.
Avoid alcohol while taking chlorphenamine as it can worsen drowsiness.
Talk to a doctor or pharmacist if you are pregnant, breastfeeding, or have other health conditions.
In this article:
Video picks for Allergy medicines
Continue reading below
Overview
Type of medicine | An antihistamine |
Used for | Allergic conditions |
Also called | Chlorpheniramine (in US); Allerief®; Hayleve®; Piriton® |
Available as | Tablets, oral liquid medicine and injection |
What is chlorphenamine used for?
Back to contentsChlorphenamine is a type of antihistamine used to relieve allergies such as:
Food allergies.
Drug allergies.
Itching caused by infections such as chickenpox.
It is also given to treat a type of allergic reaction called anaphylaxis, which is a medical emergency.
Chlorphenamine is available on prescription, or you can buy it without a prescription at pharmacies.
Continue reading below
How does chlorphenamine work?
Back to contentsChlorphenamine works by blocking the effects of histamine - a chemical that is released when the body is exposed to substances such as pollen, pet fur, peanuts, shellfish or insect bites.
Histamine causes allergic symptoms such as swelling, skin rashes, sneezing, watery eyes, and a runny or blocked nose. Chlorphenamine relieves allergic symptoms like these.
Side effects of chlorphenamine
Back to contentsCommon side effects of chlorphenamine include:
Feeling dizzy or sleepy.
Blurred vision.
Headache.
Dry mouth.
Lack of concentration.
Upset stomach.
Difficulty peeing (urinating).
Children and people over 65 years of age may be more prone to side effects from chlorphenamine.
You will find a full list of side effects in the manufacturer's information leaflet supplied with your medicine.
Continue reading below
How to manage chlorphenamine side effects
Back to contentsThe unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any continue or become troublesome.
Common chlorphenamine side effects | What can I do if I experience this? |
Feeling dizzy or sleepy, and blurred vision | Do not drive and do not use tools or machines until you feel better. Do not drink alcohol |
Headache | Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the headaches continue, stop taking chlorphenamine or ask your doctor for advice. |
Dry mouth | Try sucking sugar-free sweets or chewing sugar-free gum |
Lack of concentration, upset stomach, difficulty peeing, feeling unco-ordinated, irritability (in children) | Speak with your doctor if any of these become troublesome |
If you experience any other symptoms which you think may be due to this medicine, speak with your doctor, dentist, or pharmacist for further advice.
Who should not take chlorphenamine?
Back to contentsTo make sure that this is the right treatment for you, before you (or your child) start taking chlorphenamine it is important that you discuss the treatment with a doctor or pharmacist if:
You are pregnant or breastfeeding.
You have a problem with the way your liver works.
You have glaucoma, a condition which causes increased pressure in your eyes.
You have prostate problems, or if you have been experiencing any difficulty peeing.
You know you have a blockage in your small intestines.
You have epilepsy.
You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
You have ever had an allergic reaction to a medicine.
How to take chlorphenamine
Back to contentsRead the leaflet included with your medicine before taking chlorphenamine.
Take chlorphenamine exactly as advised by your doctor or pharmacist.
The usual recommended doses are:
Adults and children over 12: 4 mg every 4-6 hours. Maximum: 24 mg daily (12 mg daily if over 65).
Children aged 6-11: 2 mg every 4-6 hours. Maximum: 12 mg daily.
Children aged 2-5: 1 mg every 4-6 hours. Maximum: 6 mg daily.
Children aged 1-23 months: 1 mg twice daily, ideally morning and evening.
If using liquid medicine for children, measure doses carefully using the instructions on the bottle.
You can take chlorphenamine before or after food.
Stop taking chlorphenamine once your symptoms have eased.
If you miss a dose, take the next one as normal. Do not take two doses together.
Getting the most from your treatment
Back to contentsChlorphenamine can cause drowsiness. If you feel sleepy, do not drive or use machinery.
Avoid alcohol while taking chlorphenamine, as it can make drowsiness worse.
Tell your doctor or healthcare professional you are taking chlorphenamine before any operation, treatment, or allergy test.
Chlorphenamine may make your skin more sensitive to sunlight. Use sunscreen (SPF 15 or higher) and avoid sunbeds.
Check with a pharmacist before taking other medicines alongside chlorphenamine, as some can increase side effects or interact with antihistamines.
How to store chlorphenamine
Back to contentsKeep all medicines out of the reach and sight of children.
Store in a cool, dry place, away from direct heat and light.
Frequently asked questions
Back to contentsHow long does chlorphenamine take to work?
Chlorphenamine usually starts working within 30 minutes to 1 hour. Because it is a drowsy antihistamine, some people may feel sleepy soon after taking it.
The effects of chlorphenamine can last for several hours, and drowsiness may continue into the next day in some people.
Can you take chlorphenamine every day?
Chlorphenamine can be taken daily for short-term allergy relief if needed. However, long-term use should only be advised by a doctor or pharmacist.
Always follow the recommended dose and stop taking it once symptoms improve.
Can you drink alcohol while taking chlorphenamine?
It is best to avoid alcohol while taking chlorphenamine. Alcohol can increase drowsiness and make side effects worse.
Can chlorphenamine be taken with other antihistamines?
You should not take chlorphenamine with other antihistamines unless advised by a healthcare professional. Combining antihistamines can increase side effects such as drowsiness.
Can you take chlorphenamine during pregnancy?
Chlorphenamine usually can be taken during pregnancy. However, always let your doctor or midwife know that you are pregnant before taking it.
Important information about all medicines
Back to contentsImportant information about all medicines
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine ask your pharmacist.
Report side effects to a medicine or vaccine
If you experience side effects, you can report them online through the Yellow Card website.

Unsure about mixing medicines?
Check for possible interactions between medicines, supplements and foods before taking them together.
Frequently asked questions
Is chlorphenamine available without a prescription?
Chlorphenamine can be purchased without a prescription from pharmacies. It is also available on prescription from a doctor.
What is the difference between chlorphenamine and chlorpheniramine?
Chlorphenamine is the name used in the UK, while chlorpheniramine is the name used in the US for the same medicine. Both refer to this antihistamine.
Can chlorphenamine be given to very young children?
Yes, chlorphenamine can be given to children aged 1-23 months, with a recommended dose of 1 mg twice daily, ideally morning and evening. For children aged 2-5, the dose is 1 mg every 4-6 hours, with a maximum of 6 mg daily. It's important to measure liquid medicine doses carefully according to the instructions.
Are there any specific activities I should avoid while taking chlorphenamine?
You should avoid driving, operating tools, or using machinery if you feel dizzy or sleepy. It is also advised to avoid alcohol, as it can worsen drowsiness. Additionally, chlorphenamine can make your skin more sensitive to sunlight, so using sunscreen (SPF 15 or higher) and avoiding sunbeds is recommended.
Can I take chlorphenamine if I am scheduled for an operation or allergy test?
You should inform your doctor or any healthcare professional that you are taking chlorphenamine before undergoing any operation, treatment, or allergy test.
What should I do if I miss a dose of chlorphenamine?
If you miss a dose, you should take the next one as normal. Do not take two doses together to make up for the missed dose.
Further reading and references
- Manufacturer's PIL, Piriton® Tablets; Haleon UK Trading Limited, The electronic Medicines Compendium. Dated February 2023.
- Manufacturer's PIL, Piriton® Syrup; Haleon UK Trading Limited, The electronic Medicines Compendium. Dated February 2023.
Continue reading below
About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewerView full bio

Dr Colin Tidy, MRCGP
General Practitioner, Medical Author
MBBS, MRCGP, MRCP (Paediatrics), DCH
Dr Colin Tidy is an NHS Doctor, based in Oxfordshire.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Next review due: 15 Oct 2027
17 Apr 2023 | Latest version

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.