Can I take Ezetimibe and Vitamin b12 together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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There is no known interaction between ezetimibe and vitamin B12. It is safe to take these two together.
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Why this happens
Ezetimibe works by reducing the amount of cholesterol your body absorbs from food in the small intestine. Vitamin B12 is absorbed through a different pathway and does not interfere with how ezetimibe works. Likewise, ezetimibe does not prevent the body from absorbing or using vitamin B12.
What you should do
You can continue to take both ezetimibe and vitamin B12 as prescribed. No special precautions or timing changes are necessary.
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Important precautions
Liver disease
You must not take this medicine if you have moderate or severe liver disease. If you are taking it alongside a statin, your doctor will need to perform regular blood tests to check your liver function.
Unexplained muscle pain
Contact your doctor immediately if you experience unexplained muscle pain, tenderness, or weakness. This is especially important if you are taking ezetimibe in combination with a statin, as it can rarely lead to serious muscle breakdown.
Food and drink warnings
Alcohol
Drinking excessive amounts of alcohol for long periods can reduce the amount of Vitamin B12 your body is able to absorb. If you are taking B12 to treat a deficiency, it is best to keep your alcohol intake within the recommended low-risk limits.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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