Can I take Sertraline and Ibuprofen together?

It is generally recommended that you do not take sertraline and ibuprofen together as they increases your risk of internal bleeding.

Why this happens

Sertraline (an SSRI) reduces the amount of serotonin in your blood platelets, which are the cells responsible for clotting. Ibuprofen (an NSAID) also interferes with platelet function and can damage the protective lining of the stomach. When used together, these two effects combine to significantly raise the risk of a bleed.

• Speak to your doctor or pharmacist before taking these together.

• If you need pain relief, paracetamol is usually a safer choice while taking sertraline.

• If your doctor confirms you must take both, take them with food to protect your stomach.

• Seek medical help immediately if you notice signs of bleeding, such as vomit that looks like coffee grounds, very dark or tarry poo (stools), or unexplained bruising.

Stomach ulcers and bleeding

Taking these medicines together significantly increases your risk of serious stomach bleeding. Contact your doctor immediately if you notice black, tarry stools or vomit that looks like coffee grounds.

Asthma

Do not take ibuprofen if you have asthma that is worsened by aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs), as it can trigger a severe, life-threatening asthma attack.

Low sodium levels (hyponatraemia)

Sertraline can cause a dangerous drop in blood sodium levels, especially in the elderly. Seek medical help if you experience persistent confusion, muscle weakness, or seizures.

Pregnancy (third trimester)

Do not take ibuprofen if you are more than 6 months pregnant, as it can cause serious heart and kidney problems in the unborn baby and complications during birth.

Alcohol

It is best to avoid drinking alcohol while taking sertraline. Alcohol can increase the sedative effects of the medicine, making you feel more sleepy, dizzy, or unsteady. It can also worsen the symptoms of depression or anxiety.

It is best to avoid or strictly limit alcohol while taking ibuprofen. Combining alcohol with non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen increases the risk of irritation to your stomach lining and can lead to stomach ulcers or bleeding.

Grapefruit juice

You should avoid drinking large amounts of grapefruit juice while taking sertraline. Grapefruit can increase the level of sertraline in your blood, which may increase the risk of side effects.

Caffeine (Coffee, Tea, Energy Drinks)

Sertraline can sometimes make you feel restless or shaky. High amounts of caffeine can worsen these side effects or increase feelings of anxiety.

Food

Ibuprofen should ideally be taken with food or a glass of milk. This helps to protect your stomach lining and reduces the risk of indigestion or stomach ache.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.