Can I take Apixaban and Metformin together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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There is no known direct interaction between apixaban and metformin. They are generally safe to take together.
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Why this happens
Apixaban is a blood thinner (anticoagulant) and metformin is a medicine for type 2 diabetes. They work in completely different ways in the body and are processed by different organs and enzymes, so they do not interfere with each other.
What you should do
Back to contentsYou can continue taking both medicines as prescribed by your doctor. However, always ensure your doctor knows all the medications you are taking, and monitor your blood sugar levels as usual.
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Important precautions
Back to contentsSurgery or dental procedures
You must tell your surgeon or dentist you are taking apixaban before any procedure, as it increases your risk of bleeding and may need to be stopped temporarily. Do not stop taking it without medical advice.
Severe kidney disease or dehydration
Metformin must be stopped if you have severe kidney problems or become severely dehydrated (e.g., through severe vomiting or diarrhoea), as this can lead to a life-threatening build-up of acid in the blood called lactic acidosis.
Injury or falls
Because apixaban thins your blood, you must seek immediate medical attention if you have a serious fall or a blow to the head, even if you feel fine, due to the risk of internal bleeding.
Food and drink warnings
Back to contentsAlcohol
Avoid excessive alcohol consumption while taking metformin. Drinking too much alcohol, especially on an empty stomach or if you have liver problems, increases the risk of a rare but serious condition called lactic acidosis. It can also increase the risk of low blood sugar (hypoglycaemia).
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Taking these two medicines together increases the total amount of thyroid hormone in your body. This can lead to symptoms of an overactive thyroid (hyperthyroidism), such as a racing heart, feeling shaky, anxiety, or difficulty sleeping.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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