Can I take Vitamin B12 and Vitamin B2 together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
There is no known harmful interaction between vitamin B12 (cobalamin) and vitamin B2 (riboflavin). In fact, these vitamins often work together to support your health.
Why this happens
Vitamin B12 and vitamin B2 are both water-soluble vitamins from the B-complex family. They do not interfere with each other's absorption, metabolism, or excretion. Instead, they have a synergistic relationship; vitamin B2 is actually required to help convert vitamin B12 into its active form so the body can use it properly.
What you should do
It is safe to take vitamin B12 and vitamin B2 together. They are frequently found combined in B-complex supplements or multivitamins. Always follow the dosage instructions on the product label or as advised by your healthcare professional.
Food and drink warnings
Alcohol
It is best to avoid or strictly limit alcohol while taking Vitamin B12. Regular or heavy alcohol consumption can interfere with the body's ability to absorb Vitamin B12 from the gut, making the supplement less effective. Combining alcohol with medications can also increase the risk of liver damage.
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Drug interactions checker
Can I take Sertraline and Fluoxetine together?
Taking sertraline and fluoxetine together significantly increases the risk of a rare but serious condition called serotonin syndrome. This happens because both medicines work by increasing the level of a chemical called serotonin in your brain. If levels get too high, it can cause symptoms like shivering, diarrhoea, confusion, severe muscle tightness, fever, and even seizures. Additionally, fluoxetine can slow down how your body breaks down sertraline, leading to a build-up of the drug in your system and increasing the risk of side effects.

Drug interactions checker
Can I take Losartan and Vitamin D together?
There is no known direct interaction between losartan and vitamin D supplements. Taking these two together is generally considered safe.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.
More in drug interactions checker
- Can I take Alogliptin and Apixaban together?
- Can I take Amlodipine and Ginseng together?
- Can I take Atorvastatin and Bisoprolol together?
- Can I take Biotin and Isosorbide mononitrate together?
- Can I take Bisoprolol and Rybelsus (semaglutide) together?
- Can I take Black garlic and Vitamin C together?
- Can I take Calcium and Ciprofloxacin together?
- Can I take Esomeprazole and Sertraline together?
- Can I take Evana heavy period relief and Mefenamic acid together?
- Can I take Glucosamine and Vitamin B2 together?
- Can I take Lactulose and Naproxen together?
- Can I take Lercanidipine and Pregabalin together?
- Can I take Levothyroxine and Paracetamol together?
- Can I take Levothyroxine and Vitamin D together?
- Can I take Losartan and Vitamin D together?
- Can I take Morphine and Solifenacin together?
- Can I take Ramipril and Sertraline together?
- Can I take St John's wort and Contraceptive pill together?
- Can I take Venlafaxine and Vitamin D together?