Can I take Vitamin B12 and Vitamin B2 together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
There is no known harmful interaction between vitamin B12 (cobalamin) and vitamin B2 (riboflavin). In fact, these vitamins often work together to support your health.
In this article:
Video picks for Drug interactions
Continue reading below
Why this happens
Vitamin B12 and vitamin B2 are both water-soluble vitamins from the B-complex family. They do not interfere with each other's absorption, metabolism, or excretion. Instead, they have a synergistic relationship; vitamin B2 is actually required to help convert vitamin B12 into its active form so the body can use it properly.
What you should do
Back to contentsIt is safe to take vitamin B12 and vitamin B2 together. They are frequently found combined in B-complex supplements or multivitamins. Always follow the dosage instructions on the product label or as advised by your healthcare professional.
Continue reading below
Food and drink warnings
Back to contentsAlcohol
It is best to avoid or strictly limit alcohol while taking Vitamin B12. Regular or heavy alcohol consumption can interfere with the body's ability to absorb Vitamin B12 from the gut, making the supplement less effective. Combining alcohol with medications can also increase the risk of liver damage.
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions
Drug interactions checker
Can I take Sertraline and Fluoxetine together?
Taking sertraline and fluoxetine together significantly increases the risk of a rare but serious condition called serotonin syndrome. This happens because both medicines work by increasing the level of a chemical called serotonin in your brain. If levels get too high, it can cause symptoms like shivering, diarrhoea, confusion, severe muscle tightness, fever, and even seizures. Additionally, fluoxetine can slow down how your body breaks down sertraline, leading to a build-up of the drug in your system and increasing the risk of side effects.
Drug interactions checker
Can I take Danazol and Metformin together?
Danazol can make metformin less effective at lowering your blood sugar levels. This means your blood sugar might rise higher than usual while you are taking both medications.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.
Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.