Tetracycline tablets
Peer reviewed by Dr Colin Tidy, MRCGPLast updated by Michael Stewart, MRPharmSLast updated 21 Nov 2022
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Tetracycline is an antibiotic. Space out your doses during the day and make sure you continue to take the tablets until you finish the course prescribed for you.
Take tetracycline on an empty stomach-either one hour before or two hours after meals, and avoid milk for two hours before and after taking it.
Swallow the tablets with plenty of water. Sit upright or stand up as you take the tablets.
The most common side effects of tetracycline include diarrhoea, stomach upset, and tummy (abdominal) pain.
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About tetracycline
Type of medicine | A tetracycline antibiotic |
Used for | Bacterial infections; acne; rosacea |
Available as | Tablets |
What is tetracycline used for?
Tetracycline is a type of antibiotic that is used to treat bacterial infections such as chest infections, mouth infections, sexually transmitted infections, and infections resulting from some types of bites.
Tetracycline is also prescribed for some longer-term skin conditions, such as acne and rosacea.
Tetracycline works by stopping bacteria from growing and causing infection.
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Side effects of tetracycline
Common side effects of tetracycline are:
Diarrhoea.
Stomach upset.
Tummy pain.
Headache.
Blurred vision.
You will find a full list of the side effects which can be associated with your medicine on the manufacturer's printed information leaflet supplied with the medicine.
Speak with your doctor or pharmacist if any side effects continue or become troublesome.
How to manage tetracycline side effects
Tetracycline side effects | What can I do if I experience this? |
Stomach upset, tummy pain | Stick to simple foods - avoid fatty or spicy meals |
Diarrhoea | Drink plenty of water to replace lost fluids. If this continues or is severe, speak with a doctor |
Headache | Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the headaches continue, let your doctor know |
Blurred vision | Do not drive and do not use tools or machines while affected. If it continues, speak with your doctor |
Important: tetracycline can occasionally cause allergic reactions, such as a skin rash. Speak with a doctor as soon as possible if this happens to you.
If you experience any other symptoms which you think may be due to the tablets, speak with your doctor or pharmacist for further advice.
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Who should not take tetracycline?
Some medicines are not suitable for people with certain conditions. Before starting tetracycline it is important that your doctor knows:
If you are pregnant or breastfeeding. You should not take tetracycline.
If you are under 12 years of age. Tetracycline should not be taken by children.
If you have any problems with the way your liver works, or if you have any problems with the way your kidneys work.
If you have an inflammatory condition called systemic lupus erythematosus (also called lupus, or SLE), or if you have a condition causing muscle weakness, called myasthenia gravis. Tetracycline can make these conditions worse.
If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
If you have ever had an allergic reaction to a medicine.
How to take tetracycline
Read the leaflet inside the pack before starting tetracycline. It explains how the antibiotic works and lists possible side effects.
Take tetracycline exactly as your doctor tells you to. Check the label for your exact dose and schedule.
For infections: usually 3-4 doses per day.
For acne or rosacea: usually 2 doses per day.
Take your doses at the same times each day and space them evenly.
Take the tablets when your stomach is empty. This means taking your doses one hour before you eat food, or waiting until two hours after you have eaten.
Avoid milk for 2 hours before and after your dose as it can make the medicine less effective
The tablets can cause throat irritation. To prevent this, you should swallow the tablets with a large drink of water. Sit upright or stand up to take the tablets. Try to avoid taking tetracycline just before lying down, or at bedtime.
If you miss a dose, take it as soon as you remember. Try to take the correct number of doses each day, but do not take two doses together to make up for a missed dose.
Getting the most from your treatment
Treatment usually lasts about a week for infections, or several months for acne or rosacea. Finish the full course unless your doctor says otherwise.
Check with a pharmacist before taking other medicines, as some can affect tetracycline. Avoid antacids or supplements with iron, magnesium, or zinc at the same time as they reduce its effectiveness. Take them at least 2 hours before or after your dose.
Antibiotics can sometimes cause thrush (oral or vaginal). If this happens, speak to your doctor or pharmacist.
Tetracycline can make your skin more sensitive to sunlight. Avoid strong sun and sunbeds until you know how your skin reacts.
Tetracycline can stop the oral typhoid vaccine from working properly. Tell the person giving you any vaccines that you are taking this antibiotic.
How to store tetracycline
Keep all medicines out of the reach and sight of children.
Store in a cool, dry place, away from direct heat and light.
Important information about all medicines
Important information about all medicines
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.
This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine ask your pharmacist.
Report side effects to a medicine or vaccine
If you experience side effects, you can report them online through the Yellow Card website.
Frequently asked questions
How long does it take for tetracycline to work?
For most infections tetracycline starts to work after the first dose, with most people noticing improvements in their symptoms after 2-3 days. For acne it can take 6-8 weeks and for rosacea it may take several weeks to see noticeable results.
Is it safe to take tetracycline during pregnancy?
No, it is not safe to take tetracycline during pregnancy, especially after the first trimester. Tetracycline can affect the development of bones and teeth in a baby.
Can I drink alcohol while taking tetracycline?
You can drink alcohol in moderation while taking tetracycline. Alcohol does not stop tetracycline from working, however it may increase side effects such as stomach upset, dizziness, or feeling unwell. For best results, you should limit alcohol until you finish your course and feel fully recovered.
Why does tetracycline stain teeth?
Tetracycline can stain teeth because it sticks to calcium in developing teeth. Over time, this causes the teeth to change colour, starting yellow, then turning brown or grey as they’re exposed to light. Once this happens, the staining is permanent.
Why can't you take tetracycline before bed?
You should not take tetracycline before bed because lying down straight after taking it increases the chance of it getting stuck, causing irritation and possible inflammation of the throat. You should take it with a full glass of water and stay upright for at least 30 minutes afterwards.
Further reading and references
- Manufacturer's PIL, Tetracycline Tablets 250 mg; Accord-UK Ltd, The electronic Medicines Compendium. Dated November 2020.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
Next review due: 20 May 2027
21 Nov 2022 | Latest version

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