Perioral Dermatitis

Perioral dermatitis is a common skin rash that mainly affects young women. The rash affects the skin around the mouth. Use of a steroid cream on the face seems to trigger the condition in many cases. Treatment includes stopping the use of all creams and ointments to the face, including cosmetics and topical steroids. A 6- to 12-week course of antibiotics may be advised, which often clears the rash.

Perioral dermatitis is a rash that develops around the mouth. The word perioral means 'around the mouth'. Dermatitis means 'inflammation of the skin'.


Typically, small red or pink lumpy spots develop on the skin anywhere around the outside of the mouth. That is, they may appear on the chin, cheeks and the skin next to and below the nose. They look a little like acne spots but perioral dermatitis is not acne. The skin under and next to each spot is often red or pink. If there are a lot of spots next to each other then the area of affected skin can just look red and lumpy. Sometimes the skin surface can become dry and flaky.

Typically, the skin just next to the lips is not affected, or is affected much less than the skin just a little further away from the lips. So, in some cases, it looks like the rash forms almost a ring around the mouth but sparing a small border of skin next to the lips. Occasionally, the skin around the eyes is also affected.

The severity of the rash can vary from a few minor spots that are barely noticeable, to a definite and obvious lumpy rash that is around the mouth. The rash is not usually painful or itchy. However, some people report a mild burning or itchy feeling. Others report that the affected skin feels tense. The rash is not serious and is not associated with any underlying disease. However, it can be unsightly.

The exact cause is not clear. However, in many cases the rash seems to be triggered by one or more of the following:

  • Steroid creams and ointments are a main trigger. See below for details.
  • Make-up, cleansers and cosmetics applied to the area affected on the face. It may be that certain ingredients of cosmetics may act as the trigger. For example, one study found that make-up foundation seemed to be a particular provoking factor.
  • Physical factors such as strong winds and ultraviolet (UV) light.
  • Fluorinated toothpaste has been suggested as a possible trigger.
  • Yeasts and germs (bacteria) that live on the skin and in hair follicles have been suggested as a possible trigger. (However, perioral dermatitis is not just a simple skin infection.)
  • Hormone factors may play a part, as some women find that the rash becomes worse just before a period.
  • The oral contraceptive pill may be a factor in some cases.

Recently, a study has found that some sun creams used on the face may be a trigger for perioral dermatitis in some children and adults. A liquid, gel or light milk sunscreen may be the best to use.

Perioral dermatitis and steroid creams and ointments

There is a well-known link between using a topical steroid (steroid creams, gels, ointments, etc) and developing perioral dermatitis. Many cases develop soon after using a topical steroid on the face for another condition such as mild eczema. Without realising you are doing so, you may even rub some steroid on your face if you are treating another part of your body with a topical steroid. For example, you may scratch the treated area of your skin (say, your elbow), and then, without realising you are doing so, rub the finger used for scratching on to your face.

Topical steroids can also clear a mild patch of perioral dermatitis temporarily. Some people will have tried a steroid cream that can be bought at pharmacies to treat what they think is mild eczema. However, as soon as the rash clears and the steroid is stopped, the rash reappears, only even worse. This can become a vicious circle as they may then put more steroid cream on to clear the new rash, which may clear again. They may stop the steroid again but then the rash comes back even worse, etc.

Almost all cases occur in young women, most commonly between the ages of 15 and 45 years. It is thought to affect up to 1 in 100 women at some point in their lives. Perioral dermatitis is uncommon in men and children. However, as the number of men using facial skin products increases, the number of men with perioral dermatitis is increasing.

Without treatment, the condition may last for months or years. The following treatments can usually help to clear the rash. However, it may take some time for the treatment to work.

Stop using anything on your face

Firstly, your doctor is likely to advise you to stop using any cream, ointment, cosmetic, etc, on your face. In particular, your doctor may advise you to stop using any topical steroid. If you have been using a topical steroid, the rash will worsen for several days before it gets any better. You need to anticipate and accept this. Whilst the rash is present, just wash your face with water only. Some doctors advise not using toothpaste that contains fluoride.

Even when the rash has gone, it is best not to use any cosmetics or creams on the affected area, as the rash may reappear. And use only a bland liquid face cleaner to wash your face, rather than bar soap.

Antibiotic medicines

Your doctor may prescribe an antibiotic tablet in the tetracycline group. Doxycycline or tetracycline topical antibiotics are sometimes used in milder cases. The course of treatment is usually for six to twelve weeks. You may not notice any improvement for the first few weeks of treatment. However, there is an improvement in most cases within two months after starting antibiotic treatment. So, do persevere if an antibiotic is prescribed. The way antibiotics work in this condition is not clear. It is not a simple skin infection. However, tetracyclines and some other antibiotics have an action to reduce inflammation in addition to killing germs (bacteria), and this may be why they work.

Other treatments

Other treatments are sometimes used for perioral dermatitis. These include pimecrolimus cream. This cream works to reduce skin inflammation. It seems to be particularly effective in perioral dermatitis that has been caused by using topical steroids.

A medicine called isotretinoin is sometimes used in severe cases. It consists of tablets that are taken by mouth. It is also used in the treatment of acne and some other skin conditions. Isotretinoin works by slowing the production of certain substances that can cause spots to form. However, it is important that this medicine is not taken by women who are pregnant or who plan to become pregnant. This is because it may harm the developing baby or lead to miscarriage or premature birth.

Now read about Perioral Dermatitis

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Dr Laurence Knott
Peer Reviewer:
Dr Helen Huins
Document ID:
4901 (v40)
Last Checked:
13 September 2016
Next Review:
13 September 2019
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