Can I take Lansoprazole and Tramadol together?

Why this happens

Lansoprazole is a proton pump inhibitor (PPI) that reduces gastric acid. While it can alter the absorption of pH-dependent drugs, tramadol absorption is not significantly affected. Both drugs are processed by the liver (CYP enzymes), but they do not significantly interfere with each other's metabolism.

What you should do

It is generally safe to take these two medicines together. If you feel particularly dizzy or sleepy, avoid driving or operating machinery. Always follow the dosage instructions provided by your doctor or pharmacist.

Important precautions

Epilepsy or history of seizures

Tramadol can increase the risk of having a seizure, especially if you are already prone to them or are taking certain antidepressants.

Asthma or breathing problems

Tramadol can cause dangerous breathing difficulties. You must not take it if you have severe asthma or significant breathing problems.

Severe diarrhoea

Lansoprazole can increase your risk of serious bowel infections. If you develop severe or persistent watery diarrhoea, or a fever, contact your doctor immediately and do not take anti-diarrhoeal medicine.

Lupus (SLE) or skin reactions

Contact your doctor if you develop a skin rash, especially in areas exposed to the sun, as lansoprazole can cause a rare but serious autoimmune skin reaction.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol while taking lansoprazole. Alcohol increases the amount of acid your stomach produces, which can make your symptoms worse and counteract the effects of the medicine.

It is best to avoid or strictly limit alcohol while taking tramadol. Combining alcohol with tramadol significantly increases the risk of dangerous side effects, such as extreme sleepiness, breathing difficulties, and loss of consciousness.

Food (Timing)

Lansoprazole works best if you take it at least 30 minutes before food. Taking it with or after food can make it less effective at reducing stomach acid.

Caffeine (Coffee, Tea, Energy Drinks)

Lansoprazole is often prescribed for acid reflux. Caffeine can trigger or worsen reflux symptoms by relaxing the muscle at the base of the food pipe, which may make your medicine less effective at managing your symptoms.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.