Skip to main content

HIV and skin disorders

Medical Professionals

Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK and European Guidelines. You may find the HIV and AIDs article more useful, or one of our other health articles.

Approximately 90% of HIV-infected patients develop some type of skin disease1. HIV infection and its fulminant form AIDS are associated with immune deficiency, especially of the thymus-dependent system. This can lead to opportunistic infections or infections that are more rampant than normal and these infections may involve the skin. In HIV-positive children, low CD counts have been associated with infectious skin eruptions, whereas high CD counts are associated with skin disease associated with hypersensitivity reactions. A knowledge of the cutaneous manifestations of HIV can thus help to indicate the patient's immune status2.

Immune surveillance has long been postulated as a mechanism for the early detection and eradication of malignancy. There are some malignancies that are more common in this condition and some that are more aggressive.

Some cutaneous manifestations of HIV are so classical that they may lead to suspicion of the disease and early diagnosis with a greater chance of a successful outcome3. If a doctor has reason to suspect HIV and believes that a blood test is indicated, this should be made clear to the patient.

Continue reading below


After a peak of new HIV diagnoses in the UK in 2014, cases have fallen: from 6,278 in 2014 to 4,453 in 20184. This decline was particularly marked among gay and bisexual men (GBM) where diagnoses fell by 35% from 3,480 in 2014, to 2,250 in 2018. The steepest fall was observed among GBM who are white, born in the UK, aged 25 to 49 and residing in London.

The number of people diagnosed late decreased from 3,353 in 2009 to 1,883 in 2018, representing a 44% decline over the decade4. Nevertheless, the proportion of late diagnoses in 2018 remained high at 43%. There was substantial variation in sub-populations experiencing late HIV diagnosis rates. The highest rates were among black African men (65%), white men who acquired HIV heterosexually (59%), people aged over 50 years (59%) and people who inject drugs (58%).

See the separate Human Immunodeficiency Virus (HIV) article or more details.


  • Acute primary HIV infection may lead to a transient, generalised, morbilliform eruption that is most common on the trunk and occasionally on the face, arms scalp or thighs. This appears as pink macules and papules of up to 1 cm in size. Acute HIV syndrome occurs in 50-70% of recently infected patients and it occurs 3-6 weeks after exposure. There may be systemic symptoms and fever, with the rash appearing two or three days later.

  • In the early asymptomatic stage of HIV disease, no signs of infection other than lymphadenopathy are present. This stage may last for 10 years or longer.

  • As immunosuppression occurs, nonspecific skin changes occur in which common disorders have atypical features. Recurrent shingles, numerous hyperkeratotic warts, treatment-resistant seborrhoeic dermatitis and oral hairy leukoplakia are examples. The last is very highly suggestive of HIV infection and may be associated with Epstein-Barr virus (EBV).

  • In the later stages of HIV disease, chronic herpes simplex infection, molluscum contagiosum and cytomegalovirus (CMV) appear.

  • Mycobacterial infections and mucocutaneous candidiasis occur.

  • Kaposi's sarcoma (KS) can occur before the onset of immunosuppression.

  • Condylomata acuminata and verrucae appear early, without an increase in occurrence after the disease progresses, whereas herpes simplex infections, molluscum contagiosum and oral hairy leukoplakia increase as the disease advances.

  • Verrucous herpes infection, condyloma-like molluscum contagiosum and AIDS-associated pigmented or nonpigmented erythroderma may be seen.

  • Leishmaniasis and miliary tuberculosis (TB) are also reported.

Continue reading below

Kaposi's sarcoma

See also the separate Kaposi's Sarcoma article.

This was the first reported malignancy associated with HIV infection. It begins as pink macules that disseminate and become palpable. Three types have been identified - patch, plaque or nodular grade. There is often mucosal involvement but visceral disease is uncommon (affecting about 10% at diagnosis) and investigation for such involvement is not necessary in the absence of symptoms7.

The clinical progression in patients infected with HIV is more aggressive than in those who have the sarcoma without immune suppression. The advent of antiretroviral therapy (ART) has complicated the prognostic relevance of KS but it is considered that having KS as the first AIDS-defining illness combined with an increasing CD4 cell count improves prognosis, whereas having KS at >50 years conveys a poorer prognosis.

Other malignancies8

HIV increases the risk of various malignancies, including primary lymphoma of the central nervous system (CNS), undifferentiated non-Hodgkin's lymphoma, squamous cell carcinoma, anorectal carcinoma and cutaneous malignancies. AIDS-defining cancers (KS, non-Hodgkin's lymphoma and cervical cancer) with strong links to immunosuppression have reduced in incidence with the increased use of ART. The overall risk of cancer remains higher than the general population. Some of these are associated with viruses such as EBV and human papillomavirus (HPV).

  • B-cell non-Hodgkin's lymphomas may cause skin nodules.

  • Anal carcinoma and cervical intraepithelial neoplasia are associated with HPV. They tend to be more progressive and aggressive.

  • An increase in squamous cell carcinoma of the anal mucosa has been reported, especially in young men who have sex with men with HIV infection.

  • Intraoral or multiple squamous cell carcinomas, Bowen's disease and metastatic basal cell carcinoma (BCC) have occasionally been reported in patients with HIV9. The usual dictum about BCC is that it does not metastasise. However, 'eruptive' BCC has been reported, in which multiple BCCs have developed following the appearance of a single lesion in a patient with HIV9.

  • Malignant melanoma in patients with HIV appears to be more aggressive10.

  • Children with AIDS have a higher risk of developing leiomyosarcoma. The overall incidence is low but an American study reported that it has become the second most frequent malignancy in children with HIV infection or other immunodeficiency diseases11.

Continue reading below

Viral infections12

Various herpes viruses can be a problem. There may be chronic perianal and perioral herpetic ulcers caused by herpes simplex virus (HSV), recurrent typical dermatomal zoster caused by herpes zoster virus (HZV) and disseminated CMV infection.

  • Recurrent oral and anogenital HSV are common in patients with HIV and may lead to chronic ulcerations. In children, herpes simplex stomatitis is more common than varicella-zoster virus (VZV) and may become chronic and ulcerative.

  • Acute disseminated varicella-zoster infection with atypical manifestations may occur. They include hyperkeratotic papules, folliculitis, verrucous lesions, chronic ulcerations, disseminated ecthyma lesions and chronic varicella-zoster infection mimicking BCC. Varicella causes few problems in most children with HIV but occasionally it can cause fulminant chickenpox, pneumonitis, hepatitis, shingles and encephalitis13.

  • EBV has been implicated in the pathogenesis of oral hairy leukoplakia. It produces filiform white papules on the sides of the tongue. It is not pre-malignant but it may be the initial sign of progressive immunosuppression. White plaques may be confused with oral candidiasis, lichen planus and geographic tongue.

  • CMV produces ulcers in the perineal region. CMV infection has a poor prognosis with HIV.

  • Widespread or recalcitrant warts may occur on the oral mucosa, the face, the perianal region and the female genital tract. The perianal and cervical lesions may be difficult to treat. Large plantar warts are caused by HPV-66 .

  • The molluscum contagiosum virus produces small papules with central umbilication. In HIV infection, lesions may be widespread and atypical. The lesions may present on unusual sites (such as the face, neck and scalp) and the lesions may be of unusual morphology and size. Such unusual forms include solitary, endophytic, aggregated, inflamed and giant molluscum.

Fungal infections1415

They may be superficial or deep.

  • Recurrent and persistent mucocutaneous candidiasis is common with HIV infection. In the USA, recurrent vaginal candidiasis is the most common presentation of HIV infection in women. Perhaps after excluding diabetes, HIV should be considered.

  • In adults, generalised dermatophytosis or tinea capitis, which is typically caused by Trichophyton rubrum, may suggest HIV infection.

  • Pityriasis versicolor may be persistent and recurrent.

  • Deep fungal infections such as coccidiomycosis, may also produce lesions on the skin.

Bacterial infection16

  • Impetigo and folliculitis may be recurrent and persistent, especially in children.

  • Disseminated furunculosis, gingivitis, gangrenous stomatitis and abscess formation may occur.

  • Tuberculosis is more common in HIV infection. There may well be miliary TB and this can involve the skin. Mycobacterium infection is not just TB but, in endemic areas, leprosy may appear, probably in the lepromatous form as TB leprosy infers an immunological response.

  • Bacillary angiomatosis, which is caused by Bartonella henselae and rarely by Bartonella quintana, usually produces red papules and nodules.

  • Infection may occur with unusual species of mycobacterium such as Mycobacterium avium.

  • Syphilis is not confined to history but occurs more frequently in patients who have same sex partners, are bisexual or in those who use illicit drugs. Patients with syphilis have a high prevalence of HIV that may reflect multiple sexual partners and lifestyle. The ulcers of syphilis may facilitate the transmission of HIV. Patients with HIV infection with primary syphilis tend to have multiple ulcers compared with patients who are not infected with HIV. Rapid progression of secondary syphilis to tertiary syphilis occurs with HIV17. Seroconversion may be delayed and standard serological tests for syphilis may be unreliable.


Atypical or Norwegian scabies is characterised by widespread hyperkeratotic, scaly maculopapular eruptions or crusted plaques. It tends to be associated with very poor hygiene and possibly some immune inadequacy but it is also seen with HIV.

Other skin diseases

  • Seborrhoeic dermatitis or eruptions like it are seen in many patients with AIDS. Seborrhoeic dermatitis may even be the presenting feature of HIV. The eruption has widespread inflammatory and hyperkeratotic lesions and may progress to erythroderma in some patients. The incidence may be higher in patients with AIDS-related dementia or CNS disease.

  • Psoriasis and reactive arthritis are more common. In some cases, existing psoriasis may become more severe with disseminated plaques and pustules (psoriatic pustulosis).

  • The typical skin lesions of pityriasis rosea may be seen.

  • Acquired ichthyosis may begin on the lower extremities and spread in advanced disease.

  • Pruritic papular eruption (PPE) is a common cutaneous manifestation with HIV. There are small, itchy, red or skin-coloured papules on the head, neck and upper part of the trunk. It is highly indicative of advanced immunosuppression19.

  • Aphthous ulcers may be severe.

  • Thrombocytopenic purpura, vitiligo, alopecia areata, sicca syndrome, pemphigoid and other autoimmune blistering diseases have been reported with HIV disease.

  • Atopic disease may be reactivated. Atopic eczema can be severe in children.

  • Urticaria may occur primarily or as a drug eruption. Cold urticaria has also been associated with HIV disease.

  • Cutaneous vasculitis has been reported.

  • Photosensitivity is more prominent. Photo-induced lichenoid drug reactions may be seen, especially on dark skin.

Hair and nails20

  • Diffuse alopecia or alopecia areata may be inflammatory and permanent.

  • Generalised alopecia can occur after treatment with indinavir, an antiretroviral agent21.

  • Elongation of the eyelashes and softening and straightening of the scalp hair may be seen.

  • Beau's lines, telogen effluvium and pallor of the nail beds may accompany any chronic illness22.

  • Zidovudine may produce longitudinal, transverse, or diffuse melanin pigmentation of the nails but nail pigmentation has also been observed in patients with HIV who have never received the drug23.

  • Proximal subungual onychomycosis is highly suggestive of HIV disease24.

Drug reactions25

  • Morbilliform drug eruptions occur in around two thirds of patients who are treated with co-trimoxazole. This is rarely used in British general practice but it is the drug of choice for Pneumocystis jirovecii pneumonia, which is an opportunistic infection that is typical of AIDS. Reddish macules and papules can become permanent after the treatment is stopped.

  • Toxic epidermal necrolysis has been reported with antibiotics, fluconazole, clindamycin and phenobarbital in patients with HIV.

  • Drug eruptions are the most common cause of erythroderma in patients with HIV.


Management is as for the particular skin condition plus specific treatment for the HIV. Treatment may have to be more prolonged and aggressive than normal. Immunomodulatory therapy may be very useful in the treatment of viral infections associated with HIV26. Imiquimod is useful for treating anogenital warts in HIV-positive patients and may help to prevent progression to anal cancer27. It is also useful in controlling molluscum contagiosum. In KS, treatment options include ART, local radiotherapy or intralesional vinblastine for symptomatic or cosmetic improvement in early stages and chemotherapy in the advanced stage7.

Further reading and references

  1. Parker SR; The skin and HIV: no superficial matter. Top Antivir Med. 2014 Sep-Oct;22(4):680-4.
  2. Carvalho VO, Cruz CR, Marinoni LP, et al; Infectious and inflammatory skin diseases in children with HIV infection and their relation with the immune status--evaluation of 127 patients. Pediatr Dermatol. 2008 Sep-Oct;25(5):571-3.
  3. Halder S, Banerjee S, Halder A, et al; Skin diseases in HIV-infected patients: Impact of immune status and histological correlation. Indian J Sex Transm Dis. 2012 Jan;33(1):65-7. doi: 10.4103/0253-7184.93836.
  4. HIV in the United Kingdom: Towards Zero HIV transmissions by 2030; 2019 report (Data to end of December 2018), Public Health England
  5. Kreuter A, Wieland U; Oral hairy leukoplakia: a clinical indicator of immunosuppression. CMAJ. 2011 Mar 7.
  6. Hamodat M; Infectious disorders - HIV associated, 2014
  7. British HIV Association guidelines for HIV-associated malignancies 2014; British HIV Association (2014)
  8. Sigel K, Dubrow R, Silverberg M, et al; Cancer screening in patients infected with HIV. Curr HIV/AIDS Rep. 2011 Sep;8(3):142-52. doi: 10.1007/s11904-011-0085-5.
  9. Kaushal S, Merideth M, Kopparthy P, et al; Treatment of multifocal Bowen's disease in immunocompromised women with surgery and topical imiquimod. Obstet Gynecol. 2012 Feb;119(2 Pt 2):442-4. doi: 10.1097/AOG.0b013e318236f1a0.
  10. Kubica AW, Brewer JD; Melanoma in immunosuppressed patients. Mayo Clin Proc. 2012 Oct;87(10):991-1003. doi: 10.1016/j.mayocp.2012.04.018.
  11. Yin X, Wu T, Yan Y, et al; Treatment for leiomyosarcoma and leiomyoma in children with HIV infection. Cochrane Database Syst Rev. 2010 May 12;(5):CD007665. doi: 10.1002/14651858.CD007665.pub2.
  12. Simonsen M, Nahas SC, Silva Filho EV, et al; Atypical perianal herpes simplex infection in HIV-positive patients. Clinics (Sao Paulo). 2008 Feb;63(1):143-6.
  13. Gnann Jr. JW; Antiviral therapy of varicella-zoster virus infections, Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge University Press; 2007.
  14. Sharma M, Sharma R; Profile of dermatophytic and other fungal infections in jaipur. Indian J Microbiol. 2012 Jun;52(2):270-4. doi: 10.1007/s12088-011-0217-z. Epub 2011 Aug 17.
  15. Hay R, Bendeck SE, Chen S, et al; Skin Diseases - Disease Control Priorities in Developing Countries.
  16. Skin infections; aidsmap, 2015
  17. Zetola NM, Engelman J, Jensen TP, et al; Syphilis in the United States: an update for clinicians with an emphasis on HIV coinfection. Mayo Clin Proc. 2007 Sep;82(9):1091-102.
  18. Ramachandran V, Shankar EM, Devaleenal B, et al; Atypically distributed cutaneous lesions of Norwegian scabies in an HIV-positive man in South India: a case report. J Med Case Rep. 2008 Mar 14;2:82. doi: 10.1186/1752-1947-2-82.
  19. Annam V, Yelikar BR, Inamadar AC, et al; Histopathological study of pruritic papular eruptions in HIV-infected patients in relationship with CD4, CD8 counts. Indian J Pathol Microbiol. 2009 Jul-Sep;52(3):321-4.
  20. Barcaui CB, Goncalves da Silva AM, Sotto MN, et al; Stem cell apoptosis in HIV-1 alopecia. J Cutan Pathol. 2006 Oct;33(10):667-71.
  21. Woods EA, Foisy MM; Antiretroviral-Related Alopecia in HIV-Infected Patients. Ann Pharmacother. 2014 Jun 18;48(9):1187-1193.
  22. Singh G; Nails in systemic disease. Indian J Dermatol Venereol Leprol. 2011 Nov-Dec;77(6):646-51. doi: 10.4103/0378-6323.86472.
  23. Chawre SM, Pore SM, Nandeshwar MB, et al; Zidovudine-induced nail pigmentation in a 12-year-old boy. Indian J Pharmacol. 2012 Nov-Dec;44(6):801-2. doi: 10.4103/0253-7613.103306.
  24. Lee KJ, Lee YB, Lee JY, et al; Proximal Subungual Onychomycosis in a Patient with Classic Kaposi Sarcoma Caused by Trichophyton rubrum. Ann Dermatol. 2011 Sep;23 Suppl 1:S11-5. doi: 10.5021/ad.2011.23.S1.S11. Epub 2011 Sep 30.
  25. Yunihastuti E, Widhani A, Karjadi TH; Drug hypersensitivity in human immunodeficiency virus-infected patient: challenging diagnosis and management. Asia Pac Allergy. 2014 Jan;4(1):54-67. doi: 10.5415/apallergy.2014.4.1.54. Epub 2014 Jan 31.
  26. Hengge UR, Cusini M; Topical immunomodulators for the treatment of external genital warts, cutaneous warts and molluscum contagiosum. Br J Dermatol. 2003 Nov;149 Suppl 66:15-9.
  27. Newsom-Davis T, Bower M; HIV-associated anal cancer. F1000 Med Rep. 2010 Dec 8;2:85.

Article History

The information on this page is written and peer reviewed by qualified clinicians.

symptom checker

Feeling unwell?

Assess your symptoms online for free