Skip to main content

Can I take Oxypro and Shortec together?

Drug interaction guide

OxyPro and Shortec both contain the same active medicine, oxycodone. Taking them together significantly increases the amount of opioid medication in your body, which can lead to a dangerous overdose. Symptoms include extreme sleepiness, breathing difficulties (slow or shallow breathing), and loss of consciousness.

Continue reading below

Why this happens

This is a 'duplicate therapy' interaction. OxyPro is a long-acting (prolonged-release) version of oxycodone designed to release the drug slowly over 12 hours. Shortec is a short-acting (immediate-release) version designed to work quickly. Because they contain the same drug, taking both increases the total dose and the risk of side effects.

What you should do

Do not take these together unless specifically instructed by your doctor or pain specialist. Usually, a doctor will prescribe OxyPro as a 'background' painkiller and Shortec only as a 'rescue' medicine for sudden, severe pain. You must follow the exact dosage and timing on your prescription labels. If you feel very drowsy or have trouble breathing, seek emergency medical help immediately.

Continue reading below

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Continue reading below

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
flu eligibility checker

Ask, share, connect.

Browse discussions, ask questions, and share experiences across hundreds of health topics.

symptom checker

Feeling unwell?

Assess your symptoms online for free

Sign up to the Patient newsletter

Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.

Please enter a valid email address

By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.